Results 91 to 100 of about 1,036,630 (289)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Optomechanical Cavity Cooling of an Atomic Ensemble
, 2011 We demonstrate cavity sideband cooling of a single collective motional mode of an atomic ensemble down to a mean phonon occupation number of 2.0(-0.3/+0.9).
Hao Zhang +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Türk-Alman Üniversitesi Hukuk Fakültesi Dergisi, 2019 İşçilerin örgütlenerek çalışma koşullarını iyileştirmelerinde bir araç olan toplu iş sözleşmesinin imzalanmasından önceki sürecin yanı sıra, sözleşmenin devamlılığının sağlanması da önem taşır.
Esra Yiğit
doaj
Medical education in Malta : an update [PDF]
, 2009 Another academic year has come to an end, a year that has seen the finalisation of a new collective agreement for academic staff at the University of Malta, the initiation of a revamping exercise of the medical curriculum and the launching of the ...
Vassallo, Josanne
core
Critical phenomena in globally coupled excitable elements
, 2008 Critical phenomena in globally coupled excitable elements are studied by focusing on a saddle-node bifurcation at the collective level. Critical exponents that characterize divergent fluctuations of interspike intervals near the bifurcation are ...
C. L. Farrow +4 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Individual heterogeneity generates explosive system network dynamics
, 2017 Individual heterogeneity is a key characteristic of many real-world systems, from organisms to humans. However its role in determining the system's collective dynamics is typically not well understood.
Johnson, Neil F., Manrique, Pedro D.
core +1 more source