Results 71 to 80 of about 25,352 (302)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A comprehensive view of nuclear shapes, rotations and vibrations from fully quantum mechanical perspectives [PDF]

EPJ Web of Conferences
The nuclear quadrupole collective states at low excitation energies are described in a novel, fully quantum mechanical and systematic manner as compared to traditional pictures initiated by Aage Bohr.
Otsuka Takaharu
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Empirical investigation of extreme single-particle behavior of nuclear quadrupole moments in highly collective A∼150 superdeformed bands

, 2001
The intrinsic quadrupole moment Q0 of superdeformed rotational bands in A∼150 nuclei depends on the associated single-particle configuration. We have derived an empirical formula based on the additivity of effective quadrupole moments of single-particle ...
Lane, G.J., Macchiavelli, A.O., Janssens, R.V.F., Clark, R.M., Fallon, P., Floor, S.N., Sanders, S.J., Svensson, C.E., Clark, S.T., Norris, J., Hackman, G.   +10 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Studies of positive-parity low-spin states in the A = 150 region

EPJ Web of Conferences, 2018
A systematic investigation of low-lying levels of nuclides in the mass 150 region has been undertaken at iThemba LABS. An extensive set of data on the low-lying, positive-parity bands in the nuclides between N = 88 and 92 and Sm to Yb has been obtained ...
Bark Robert, Li Zhipan, Majola Siyabonga, Sharpey-Schafer John, Shi Zhi, Zhang Shuangquan   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Peculiar Spatiotemporal Behavior of Unstable Plastic Flow in an AlMgMnScZr Alloy with Coarse and Ultrafine Grains

Metals, 2017
The work addresses the effects of nanosize particles and grain refinement on the patterns of stress serrations and kinematics of deformation bands associated with the Portevin–Le Chatelier instability of plastic flow.
Daria Zhemchuzhnikova, Mikhail Lebyodkin, Tatiana Lebedkina, Anna Mogucheva, Diana Yuzbekova, Rustam Kaibyshev   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Double stop-band structure near half-integer tunes in high-intensity rings

Physical Review Accelerators and Beams, 2016
This paper addresses a detailed experimental study of collective instability bands generated near every half-integer tune per lattice period by coherent dipole and quadrupole resonances.
K. Moriya, M. Ota, K. Fukushima, M. Yamaguchi, K. Ito, H. Okamoto   +5 more
doaj   +1 more source