Results 91 to 100 of about 25,352 (302)
Microscopic analysis of quadrupole-octupole shape evolution
EPJ Web of Conferences, 2015 We analyze the quadrupole-octupole collective states based on the microscopic energy density functional framework. By mapping the deformation constrained self-consistent axially symmetric mean-field energy surfaces onto the equivalent Hamiltonian of the ...
Nomura Kosuke
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Effects of non-uniform distributions of gain and loss in photonic crystals
New Journal of Physics, 2016 We present a ${\bf{k}}\cdot {\bf{p}}$ theory of photonic crystals containing gain and loss in which the gain and loss are added to separate primitive cells of the underlying Hermitian system, thereby creating a supercell photonic crystal.
Alexander Cerjan, Shanhui Fan
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Collective Self-Assessment in Banded Mongoose Intergroup Contests
Behavioral EcologyContests over resources are widespread in nature. To optimize outcomes, animals assess fighting abilities, deciding to escalate conflicts based on their own strength (self-assessment) or comparing their own strength with that of their rival (mutual assessment).
C W Rayner +6 more
openaire +3 more sources
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Extracting accurate light–matter couplings from disordered polaritons
NanophotonicsThe vacuum Rabi splitting (VRS) in molecular polaritons stands as a fundamental measure of collective light–matter coupling. Despite its significance, the impact of molecular disorder on VRS is not fully understood yet.
Schwennicke Kai +2 more
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