Results 71 to 80 of about 58,996 (261)

Probabilistic dose assessment for personnel during decommissioning of spent nuclear fuel storage facility of transportable NPP “Pamir-630D”

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2019
The aim of the current work is to perform a probabilistic dose assessment to quantify the relative importance of the source data uncertainties contribution towards the uncertainty estimates of collective and maximum individual doses of personnel during ...
A. V. Kuzmin, A. V. Radkevich, V. P. Petrushkevich, N. D. Kuzmina   +3 more
doaj   +1 more source

Collection and Analysis of Drug Information on Pediatric Doses.

Japanese Journal of Hospital Pharmacy, 1992
Pediatric doses cited in package inserts were compared between Japanese formulary “Drugs in Japan, Ethical Drugs 1974” and “Drugs in Japan, Ethical Drugs 1989” in order to compare the extent of citation of pediatric doses in recent package inserts with that of 15 years before.
ARIMORI, KAZUHIKO, MORIYAMA, YUHSUKE, NAKANO, MASAHIRO   +2 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

THE OUTCOMES OF FUNCTIONING OF UNIFIED SYSTEM OF INDIVIDUAL DOSE CONTROL OF RUSSIAN FEDERATION CITIZENS BASED ON 2014 DATA

Радиационная гигиена, 2015
The article presents the outcomes of the generalized analysis of personnel, patients and population radiation doses information obtained from the Unified System of Individual Dose Control (USIDC) for 2014.
V. S. Repin, N. K. Baryshkov, A. A. Bratilova, K. V. Varfolomeeva, Ju. N. Goncharova, D. V. Kononenko, T. A. Kormanovskaja, S. I. Kuvshinnikov, L. V. Repin, I. K. Romanovich, A. V. Svetovidov, I. P. Stamat, O. E. Tutel’jan   +12 more
doaj  

Evolution of the collective radiation dose of nuclear reactors from the 2nd through to the 3rd generation and 4th generation sodium-cooled fast reactors

EPJ Nuclear Sciences & Technologies, 2017
During the operation of a nuclear reactor, the external individual doses received by the personnel are measured and recorded, in conformity with the regulations in force.
Guidez Joel, Saturnin Anne
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

MODERN PECULIARITIES OF THE MEDICAL EXPOSURE LEVELS FORMING OF THE TATARSTAN REPUBLIC POPULATION DURING X-RAY PROCEDURES IMPLEMENTATION

Радиационная гигиена, 2015
The purpose. The purpose of the investigation is an assessment of the peculiarities of forming and registration of the collective doses of patients and the population of the Tatarsatan Republic (RT) from medical exposure and the development of measures ...
S. A. Ryzhkin, S. I. Ivanov, M. A. Patjashina, R. K. Ismagilov, N. A. Akopova, S. V. Loginova, D. R. Nasybullin   +6 more
doaj  

Why the Same Dose of Botulinum Toxin A Is Less Predictable in Small Muscles: A Discrete Threshold Model

Toxins
Pharmacodynamic models of botulinum toxin type A map a mean concentration onto a smooth dose–response curve, yet the outcome is binary and arises from a finite population of near-threshold motor units.
Andrea Felice Armenti, Francesco Armenti
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source