Results 51 to 60 of about 58,996 (261)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
eLife, 2016 Collective migration is a complex process that contributes to build precise tissue and organ architecture. Several molecules implicated in cell interactions also control collective migration, but their precise role and the finely tuned expression that ...
Tripti Gupta +4 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Радиационная гигиена, 2016 This article is aimed at methodology development for collective risk assessment of medical irradiation, basing on results of radiation-hygienic passportization in the Russian Federation regions, i.e.
V. Ju. Golikov
doaj
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
环境与职业医学BackgroundWith the widespread application of ionizing radiation technology in non-medical fields, the number of non-medical radiation workers has steadily increased over the years.
Tong HUANG +6 more
doaj +1 more source
Do you know the radiation dose your patients receive from your CT scanner?
South African Journal of Radiology, 2001 The number of computed tomography (CT) examinations and new indications for CT are increasing in frequency worldwide. While CT makes up only 4% of medical examinations, it might contribute as much as 40% of the total collective radiation dose to the ...
Chris Welman +2 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Science and Technology of Nuclear Installations, 2017 The optimization of radiation protection is an important task in both the design and operation of a nuclear power plant. Although this topic has been considerably investigated for pressurized water reactors, there are very few public reports on it for ...
Sida Sun, Hong Li, Sheng Fang
doaj +1 more source