Results 61 to 70 of about 869,083 (297)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

How dissipation constrains fluctuations in nonequilibrium liquids: Diffusion, structure and biased interactions

open access: yes, 2019
The dynamics and structure of nonequilibrium liquids, driven by non-conservative forces which can be either external or internal, generically hold the signature of the net dissipation of energy in the thermostat.
Fodor, Étienne   +3 more
core   +1 more source

Natural resources conservation management and strategies in agriculture [PDF]

open access: yes, 2013
This paper suggests a holistic framework for assessment and improvement of management strategies for conservation of natural resources in agriculture.
Bachev, Hrabrin
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Energy commoning. The politicization of energy collective action in Southern Europe

open access: yesRassegna Italiana di Sociologia
The shift towards more sustainable energy systems representsthe core of the socio-ecological transition narrative and perhapsthe most complex element to address because it would notonly require an overall reconception of the material and digitalinfrastructure, but also the institutional settings and the socialpractices that permeate it.
Andrea Taffuri   +5 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Ultra Low Momentum Neutron Catalyzed Nuclear Reactions on Metallic Hydride Surfaces

open access: yes, 2005
Ultra low momentum neutron catalyzed nuclear reactions in metallic hydride system surfaces are discussed. Weak interaction catalysis initially occurs when neutrons (along with neutrinos) are produced from the protons which capture ``heavy'' electrons ...
A. Widom   +17 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

A Community Energy Transition Model for Urban Areas: The Energy Self-Reliant Village Program in Seoul, South Korea

open access: yes, 2017
While community energy initiatives are on the rise, community actions for energy transition in Asian countries have rarely been studied. While it is difficult for community energy initiatives to develop spontaneously in Seoul, there are some success ...
Hana Kim
semanticscholar   +1 more source

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