Results 71 to 80 of about 232,783 (214)

Social determinants of health: critical consciousness as the core to collective impact. [PDF]

Front Res Metr Anal, 2023
Doll J, Malloy J, Gonzales R.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pathways to engaging in community-centered earthquake science: Lessons learned and tangible tools

Seismica
Although the importance of building meaningful connections between earthquake science research and local communities is widely recognized, the pathways to achieving such collaboration are not always clear, actionable, or well-supported in current ...
Yolanda C. Lin, Aaron A. Velasco, Marianne S. Karplus, Susan L. Bilek, Jeffrey Weidner, Monica Alvillar, Conevery Bolton Valencius, Michael R. Brudzinski, Divya Chandrasekhar, John E. Ebel, Tiegan E. Hobbs, Steven C Jaumé, Eric C. Jones, Alan L. Kafka, Anne-Marie Núñez, Kristine L. Pankow, Zhigang Peng, Iris Tien, Elizabeth Vanacore   +18 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Analysis of the Impact of Ownership Type on Construction Land Prices Under the Influence of Government Decision-Making Behaviors in China: Empirical Research Based on Micro-Level Land Transaction Data

Land
Under China’s dual land ownership system, the use rights of urban land (state-owned) and rural land (collective-owned) are not equal. Understanding the roles of ownership type and government decision-making behaviors in the formation of land prices is ...
Jinlong Duan, Zizhou Ma, Fan Dong, Xiaoping Zhou   +3 more
doaj   +1 more source

Advancing positive social determinants of health through collective impact and the 100% New Mexico Model. [PDF]

Arch Public Health, 2023
McCrae JS, Spain AK.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Growing CAPITOL (Critical Age Periods Impacting the Trajectory of Obesogenic Lifestyles) 4 Life

Journal of Multidisciplinary Healthcare
Andrew P Hills,1 Kylie Burgess,2 Kylie Mulcahy,2 Sisitha Jayasinghe,3 Kira Coghlan,2 Nuala M Byrne,1 Lisa M Dalton,1 Kiran DK Ahuja,1 Roger Hughes4 1School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS ...
Hills AP, Burgess K, Mulcahy K, Jayasinghe S, Coghlan K, Byrne NM, Dalton LM, Ahuja KDK, Hughes R   +8 more
doaj