Results 41 to 50 of about 8,466,757 (309)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Out of Scope Employees in Turkish Collective Bargaining System [PDF]
, 2016 Collective Bargaining is the process in which labor unions representing workers on the one hand and employers or employers’ institutions on the other gather and come to the table in order to determine working rules and conditions of both parties and the ...
Aşçı, Mehmet Saim; Istanbul Medipol University
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Ch. 6. Remembering, Forgetting, and Rewriting the Past: Athenian Inscriptions and Collective Memory
Histos, 2020 This chapter explores the ways in which the Athenians responded to inscriptions after their creation, and in particular their approaches to the emendation, destruction, and recreation of inscribed public texts.
Polly Low
doaj +1 more source
Treatment of Prostatic Abscess: Case Collection and Comparison of Treatment Methods [PDF]
Korean Journal of Urology, 2012 Prostatic abscess is an uncommon urologic disease but has a high mortality rate if not treated properly. Furthermore, diagnosis and proper treatment of prostatic abscesses remains a challenge for physicians. Therefore, we compared data on conservative treatments, transurethral resection of prostatic abscess, and transrectal ultrasound (TRUS)-guided ...
Jang, Kidon +3 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Veterinary ResearchBovine respiratory disease (BRD) is a major health challenge for young bulls. To minimize economic losses, collective treatments have been widely adopted.
Carolina Merca +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Youth Research Collective Life Patterns Project - Cohort 2
Life Patterns is an Australian Research Council funded project following the lives of young Australians since the 1990s. The project has followed two cohorts of young Australians during the last 30 years: Cohort 1 who were aged 18 in 1991 and Cohort 2 ...
Youth Research Collective
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source