Results 101 to 110 of about 71,521 (248)

Collectives in Cases of Human-Machine Interaction: A Pragmatic Defense of Human-Machine Collectives

open access: yesHuman-Machine Communication Journal
Humanity’s future will include greater integration with different kinds of increasingly autonomous and interactive technological systems. Doing so is likely to confront us with reasons to adapt some of our currently accepted concepts and practices.
Niel H. Conradie   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Enquêtes collectives en sciences sociales

open access: yes, 2014
Ce colloque organisé par le CESAER et la Maison des sciences de l'Homme de Dijon s’adresse à l’ensemble des chercheurs en sciences humaines et sociales.

core  

The designer collective as a social system of professional learning and development

open access: yesFORMakademisk
This study examines designer collectives as social systems of professional learning and development. Based on a qualitative single case study of a contemporary Danish designer collective, the study analyses seven core members’ experiences of ...
Nicky Nedergaard
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Lviv medical community in 1930s: between hope and challenge [PDF]

open access: yes, 2019
Materials of International Workshop "Ludwik Fleck and His Thought Collectives" (April 11-14 ...
Hnatiuk, Ola
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

SUSTAINABLE DEVELOPMENT GOALS AS DOXA IN THE NETWORK PRACTICE OF ART COLLECTIVES IN INDONESIA

open access: yesJurnal Kajian Seni
This study examine the phenomenon of networks of art collectives in Indonesia, which proliferated in the period leading up to 2020, and their connection to the global discourse of the Sustainable Development Goals.
Hidayatul Azmi
doaj   +1 more source

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