Results 91 to 100 of about 10,468,042 (264)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
, 1937 The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
, 1901 The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
, 1944 The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
BMC Public HealthBackground HPV vaccination is highly effective in preventing HPV infection and subsequent precancers and invasive cancers related to HPV. Unfortunately, vaccine coverage in the U.S. lags behind national and global targets.
Erica Liebermann +4 more
doaj +1 more source
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
, 1973 The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source