Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Neuregulin 4 in Insulin Resistance: Mechanisms, Controversies, and Therapeutic Perspectives
Zhiheng Qiao,1 Xiaocan Gai,1 Hongyang He,1 Guoliang Ji,1 Haixin Zhang,1 Shumin Liu21School of Graduate Students, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2Basic Medical College, Heilongjiang ...
Qiao Z +5 more
doaj
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
Protocol for quantifying miRNA trafficking across the endosomal membrane
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source

