Results 61 to 70 of about 378,378 (264)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Upward Bound Program Supports Success of Low-Income and/or First-Generation College Students at a STEM-Focused HSI

Education Sciences
A deeper understanding of low-income and first-generation college student experiences is essential to advancing diversity and equity in higher education.
Brooklin Hensley, Theresa Apodaca, Megha Khandelwal   +2 more
doaj   +1 more source

The Relationship Between Trait Mindfulness and Well-Being in College Students: The Serial Mediation Role of Flow Experience and Sports Participation

Psychology Research and Behavior Management, 2023
Pengfei Lin Department of Physical Education, Shandong Management University, Jina, People’s Republic of ChinaCorrespondence: Pengfei Lin, Email feixue200330@126.comPurpose: The current college students have a lot of mental pressure due to their heavy ...
Lin P
doaj  

Student Perceptions of College Faculty Who Use OER

International Review of Research in Open and Distributed Learning, 2017
Research indicates that students find open educational resources (OER) favorable, but there is no research regarding students’ perceptions of faculty who use open textbooks.
Gabrielle Vojtech, Judy Grissett
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Perceptions of Consent Among College Students: The Effects of Perpetrator, Target, and Perceiver Gender

Ex Aequo: Revista da Associação Portuguesa de Estudos sobre as Mulheres
Sexual assault is prevalent on college campuses, undermining student safety and success. About 1 in 4 female and 1 in 14 male undergraduates experience sexual violence (Cantor et al. 2019).
Frank Kotey, Maureen C. Kenny , Jasmin Hernandez   +2 more
doaj   +1 more source

Predictors of Cycling in College Students

Journal of American College Health, 2013
To (1) assess cycling-related questions that have been added to the electronic version of the American College Health Association National College Health Assessment II (ACHA-NCHA), (2) examine cycling prevalence, and (3) identify predictors of cycling in college students.Predominately female (69%), undergraduate (89%), and white (85%) students (N = 949)
Ransdell, Lynda B., Mason, Susan G., Wuerzer, Thomas, Leung, Ka Man   +3 more
openaire   +4 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source