Results 61 to 70 of about 9,957,383 (309)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Return of Inorganic Substance Poisoning as a Method of Suicide. An Analysis of Autopsy Reports from 2018-2023 with a Discussion of the Phenomenon = Powrót zatruć substancjami nieorganicznymi jako metody samobójstwa. Analiza protokołów sekcyjnych z lat 2018-2023 wraz z omówieniem zjawiska

Archives of Forensic Medicine and Criminology
Cel pracy: Opisanie znalezisk sekcyjnych ofiar samobójstw z użyciem związków nieorganicznych z ostatnich 5 lat i próba wyjaśnienia zjawiska powrotu tych substancji jako środków do zatruć samobójczych.
Łukasz Marczyk, Marcin Skorupa, Kacper Gil, Bartłomiej Cytlau, Joanna Augustyn, Aleksandra Łach, Tomasz Konopka   +6 more
doaj   +1 more source

IGBT Based Four Quadrant Chopper Drive Closed Loop Control for DC [PDF]

E3S Web of Conferences
These manuscripts present a closed-loop IGBT-based fourquadrant chopper drive system for DC motors. This paper intends to improve DC motor control’s accuracy, effectiveness, and adaptability in a variety of applications.
Santhosh K., Sree Jyothi Khammapati R., Anusha D., Rajkumar Bhukya, Venu Enuganti, Jagadish V.   +5 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Assessing the Satisfaction Rate among Patients in terms of Effective Communication Skills of General Physicians Across the Walk-in Medical Clinics of Karachi Pakistan

Journal of the Dow University of Health Sciences, 2010
Family Practice is the medical specialty concernedwith the total health care o f the individual and thefamily, integrates the biological, clinical and behavioralsciences.
Ayesha Hameed, Anas Ibrahim Bawahab, Sana Wahab, fauzia imtiaz   +3 more
doaj   +2 more sources

Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook

, 1916
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook

, 1908
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core