Results 61 to 70 of about 10,468,042 (264)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Assessing the Satisfaction Rate among Patients in terms of Effective Communication Skills of General Physicians Across the Walk-in Medical Clinics of Karachi Pakistan

Journal of the Dow University of Health Sciences, 2010
Family Practice is the medical specialty concernedwith the total health care o f the individual and thefamily, integrates the biological, clinical and behavioralsciences.
Ayesha Hameed, Anas Ibrahim Bawahab, Sana Wahab, fauzia imtiaz   +3 more
doaj   +2 more sources

Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook

, 1916
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

IGBT Based Four Quadrant Chopper Drive Closed Loop Control for DC [PDF]

E3S Web of Conferences
These manuscripts present a closed-loop IGBT-based fourquadrant chopper drive system for DC motors. This paper intends to improve DC motor control’s accuracy, effectiveness, and adaptability in a variety of applications.
Santhosh K., Sree Jyothi Khammapati R., Anusha D., Rajkumar Bhukya, Venu Enuganti, Jagadish V.   +5 more
doaj   +1 more source

Yearbook (Gettysburg College); Gettysburg College spectrum; Gettysburg College yearbook

, 1899
The Spectrum yearbook contains images and text created by students during their time at Gettysburg College. Offensive content can be found on these pages and does not represent the College’s values.
Gettysburg College
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Liver-nervous system axis in MASLD: mechanistic insights and emerging targeted therapies

eGastroenterology
The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) extends beyond intrinsic hepatic metabolic defects, involving critical bidirectional communication between the liver and the central nervous system—termed the liver ...
Xin Wang, Hua Wang, LI Zuo, Wajahat Mehal, Yinuo Yuan, Jianlei Zhang, Junzhe Guo, Boya Sheng, Jinwei Xu   +8 more
doaj   +1 more source

First-Generation College Students

Journal of College Orientation, Transition, and Retention, 2013
First-generation students’ transitions are particularly important to their success in college. Though attention to and support for first-generation students on college campuses have increased in recent decades, these efforts remain campus-centric ...
Elizabeth Buffy Stoll
doaj   +1 more source