Results 41 to 50 of about 9,957,383 (309)

Fostering innovation and building youth capacity in global health: design, implementation, and evaluation of a youth-led digital health hackathon

BMC Medical Education
Background African countries face significant challenges in their healthcare systems, including inadequate human resources, insufficient budgetary allocation, and poor leadership and management.
Victor Oluwafemi Femi-Lawal, Olaoluwaposi Emmanuel Ogunlana, Temilola Aderemi, Olutola Vivian Awosiku, Stephen Igwe, Adetayo Adetokun, Umulkhairah Onyioiza Arama, Marvellous Adelaja, Oluwagbemisola Akinjobi, Gift Dansu, Peter Abolarin, Chijioke Mgbeobukwa, Sean Anointed   +12 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Kalamazoo College Alumnus (December, 1950)

, 1950
20 p. : ill., ports.The Cover Picture: Sir Gladwyn Jebb -- Kalamazoo College Receives National Honor -- Book Drive -- Annual Christmas Carols Given Dec. 9 -- "Impressions of Homecoming" / Edgar L.
Kalamazoo College, Kalamazoo College Alumni Association   +1 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using the Exercise Is Medicine® on Campus Platform to Assess College Students’ Practice of Physical Activity in a Rural Setting

Journal of the Georgia Public Health Association, 2016
Background: The college setting offers public health educators and exercise scientists a favorable environment to implement wide-spread change in levels of physical activities. With over two-thirds of all adults in the U.S.
Bridget Melton, Jazmin Williamson, Helen Bland, Jian Zhang   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Kalamazoo College Alumnus (October, 1952)

, 1952
16 p. : ill., ports.Director of Admissions Writes to Our Alumni -- Across the President's Desk / John Scott Everton -- Kalamazoo College Begins 120th Year -- Annual Fund Drive Set for November -- Foreign Students at "K" -- Religious Aspect of the ...
Kalamazoo College, Kalamazoo College Alumni Association   +1 more
core   +1 more source

Negative life events and college students’ adjustment: the mediating role of self-esteem and the moderating role of grade

Frontiers in Psychology
The present research explored the relationship among negative life events, self-esteem, grade, and adjustment of college students. In total, 1,717 college students were investigated by the adolescent life events scale, Rosenberg self-esteem inventory ...
Xiaoshan Quan, Ji Sun, Ji Sun
doaj   +1 more source

College Students Today…

Journal of College Orientation, Transition, and Retention, 2018
College students today are regularly accused of being under-prepared and under-motivated, yet they are also under intense pressure to pick a major, graduate in four years, and be prepared to work in fields that do not yet exist.
Jennifer L. Bloom
doaj   +1 more source