Results 31 to 40 of about 10,468,042 (264)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Fostering innovation and building youth capacity in global health: design, implementation, and evaluation of a youth-led digital health hackathon

BMC Medical Education
Background African countries face significant challenges in their healthcare systems, including inadequate human resources, insufficient budgetary allocation, and poor leadership and management.
Victor Oluwafemi Femi-Lawal, Olaoluwaposi Emmanuel Ogunlana, Temilola Aderemi, Olutola Vivian Awosiku, Stephen Igwe, Adetayo Adetokun, Umulkhairah Onyioiza Arama, Marvellous Adelaja, Oluwagbemisola Akinjobi, Gift Dansu, Peter Abolarin, Chijioke Mgbeobukwa, Sean Anointed   +12 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Kalamazoo College : Where Chaos is a Work of Art

, 1991
200 p. : ill. ; 29 cm.Original scanned at 250 dpi.To obtain permission to reproduce, please contact the Kalamazoo College Archives at archives@kzoo.edu.The Boiling Pot, 1991, Kalamazoo College yearbook.
Kalamazoo College
core   +1 more source

Are the healers healthy? Exploring non-communicable diseases among healthcare workers in Ajman, United Arab Emirates

BMC Public Health
Background Non-communicable diseases (NCDs), particularly cardiovascular diseases, are a major cause of global mortality. In the Gulf Cooperation Council (GCC) nations, healthcare workers face increased risks of obesity, hypertension, and diabetes due to
Sandhra Treesa Santhosh, Abubakker Siddiq Mohamed Hameed, Anugraha Lisa Ciju, Aaesha Rannath, Syeda Kaunain Fatima, Janet Chichu James, Mohammed Nayeem Shaji, Ehab M Esheiba, Jayadevan Sreedharan, Jayakumary Muttappallymyalil   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Proposed Strategies for Sustainable Agriculture Domain Chatbot with Blockchain Development [PDF]

Journal of Cognitive Human-Computer Interaction
The farm sector is challenged by various factors, such as climate volatility, ineffective resource management, and data security. In this paper, a new methodology is proposed where blockchain technology is combined with a chatbot platform to offer ...
S. Rahini Sudha, Uma mageshwari D., Vaishnavi N. G., Sumetha S. S., Subbalakshmi B. V., Poovizhi A.   +5 more
doaj   +1 more source