Results 201 to 210 of about 11,604 (291)

Probing Early α‐Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion‐Mobility Mass Spectrometry and Fluorescence Spectroscopy

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Misfolding and aggregation of α‐Synuclein (α‐Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α‐Syn segments, the NACore (68GAVVTGVTAVA78, WT‐PD1) and the preNAC region (47GVVHGVATVA56, WT‐PD2), using high‐resolution trapped ion ...
Agathe Depraz Depland   +3 more
wiley   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim   +4 more
wiley   +1 more source

Electronic Correlation Effects in the Response of Graphene and MoS2 Monolayers to the Impact of Highly‐Charged Ions

open access: yesphysica status solidi (b), EarlyView.
The response of graphene and MoS2 monolayers to highly‐charged impinging ions is investigated using nonequilibrium Green functions theory. Electronic correlations are found to have a significantly stronger influence on the ultrafast ion‐induced electron dynamics in MoS2 than in graphene.
Giorgio Lovato   +4 more
wiley   +1 more source

Performance evaluation of regional weather predictions with the Model for Prediction Across Scales – Atmosphere (MPAS‐A) over the Maritime Continent

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
As part of the ongoing efforts to develop next‐generation forecasting systems at the Meteorological Service Singapore, this study presents the setup and evaluation of the SINGV_NG(MPAS) system. Overall, the SINGV_NG(MPAS) system outperforms European Centre for Medium‐Range Weather Forecasts (ECMWF) deterministic forecasts in capturing heavy rainfall ...
I‐Han Chen   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy