Results 11 to 20 of about 279,038 (339)

Coloc-stats: a unified web interface to perform colocalization analysis of genomic features [PDF]

Nucleic Acids Research, 2018
Functional genomics assays produce sets of genomic regions as one of their main outputs. To biologically interpret such region-sets, researchers often use colocalization analysis, where the statistical significance of colocalization (overlap, spatial proximity) between two or more region-sets is tested.
Boris Simovski, Chakravarthi Kanduri, Sveinung Gundersen, Dmytro Titov, Diana Domanska, Christoph Bock, Lara Bossini-Castillo, Maria Chikina, Alexander Favorov, Ryan M Layer, Andrey A Mironov, Aaron R Quinlan, Nathan C Sheffield, Gosia Trynka, Geir K Sandve   +14 more
openaire   +5 more sources

Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches

American Journal of Human Genetics, 2022
Summary Mendelian randomization and colocalization are two statistical approaches that can be applied to summarized data from genome-wide association studies (GWASs) to understand relationships between traits and diseases.
V. Zuber, Nastasiya F. Grinberg, D. Gill, Ichcha Manipur, E. Slob, Ashish Patel, C. Wallace, S. Burgess   +7 more
semanticscholar   +1 more source

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses

EBioMedicine, 2023
Summary Background Identifying new drug targets for inflammatory bowel disease (IBD) is urgently needed. The proteome is a major source of therapeutic targets.
Jie Chen, Fengzhe Xu, Xixian Ruan, Jing Sun, Yao-Chen Zhang, Han Zhang, Jianhui Zhao, Jie Zheng, S. Larsson, Xiao-Yang Wang, Xia Li, S. Yuan   +11 more
semanticscholar   +1 more source

Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses

Cell Reports Medicine, 2023
Summary We conduct proteome-wide Mendelian randomization and colocalization analyses to decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic complications.
S. Yuan, Fengzhe Xu, Xue Li, Jie Chen, Jie Zheng, C. Mantzoros, S. Larsson   +6 more
semanticscholar   +1 more source

Scalable and model-free detection of spatial patterns and colocalization

bioRxiv, 2022
The expeditious growth in spatial omics technologies enable profiling genome-wide molecular events at molecular and single-cell resolution, highlighting a need for fast and reliable methods to characterize spatial patterns.
Qi Liu, Chih-Yuan Hsu, Y. Shyr
semanticscholar   +1 more source

ColocQuiaL: A QTL-GWAS colocalization pipeline [PDF]

Bioinformatics, 2021
AbstractSummaryIdentifying genomic features responsible for genome-wide association study (GWAS) signals has proven to be a difficult challenge; many researchers have turned to colocalization analysis of GWAS signals with expression quantitative trait loci (eQTL) and splicing quantitative trait loci (sQTL) to connect GWAS signals to candidate causal ...
Brian Y. Chen, William P. Bone, Kimberly Lorenz, Michael Levin, Marylyn D. Ritchie, Benjamin F. Voight   +5 more
openaire   +2 more sources

ezQTL: A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci

bioRxiv, 2022
Genome-wide association studies (GWASs) have identified thousands of genomic loci associated with complex diseases and traits, including cancer. The vast majority of common trait-associated variants identified via GWAS fall in non-coding regions of the ...
Tongwu Zhang, A. Klein, Jian Sang, Jiyeon Choi, K. Brown   +4 more
semanticscholar   +1 more source

Microscale Colocalization of Cascade Enzymes Yields Activity Enhancement.

ACS Nano, 2022
Colocalization of cascade enzymes is broadly discussed as a phenomenon that can boost the cascade reaction throughput, although a direct experimental verification is often challenging.
Yan Xiong, S. Tsitkov, H. Hess, O. Gang, Yifei Zhang   +4 more
semanticscholar   +1 more source

Shortcuts through colocation facilities [PDF]

Proceedings of the 2017 Internet Measurement Conference, 2017
In Proceedings of the ACM Internet Measurement Conference (IMC '17), London, GB ...
Vasileios Kotronis, George Nomikos, Lefteris Manassakis, Dimitris Mavrommatis, Xenofontas Dimitropoulos   +4 more
openaire   +2 more sources

Improved immunoassay sensitivity and specificity using single-molecule colocalization

Nature Communications, 2021
Enzyme-linked immunosorbent assays (ELISAs) are a cornerstone of modern molecular detection, but the technique still faces notable challenges. One of the biggest problems is discriminating true signal generated by target molecules versus non-specific ...
Amani A. Hariri, Sharon S. Newman, Steven J. Tan, Dan Mamerow, Alexandra Adams, Nicolò Maganzini, B. Zhong, M. Eisenstein, A. Dunn, H. T. Soh   +9 more
semanticscholar   +1 more source