Results 31 to 40 of about 279,038 (339)

Secretagogin as a marker to distinguish between different neuron types in human frontal and temporal cortex

Frontiers in Neuroanatomy, 2023
The principal aim of the present work was to chemically characterize the population of neurons labeled for the calcium binding protein secretagogin (SCGN) in the human frontal and temporal cortices (Brodmann’s area 10 and 21, respectively). Both cortical
Silvia Tapia-González, Silvia Tapia-González, Silvia Tapia-González, Javier DeFelipe, Javier DeFelipe, Javier DeFelipe   +5 more
doaj   +1 more source

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]

, 2019
The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine, Bock-Bierbaum, Tobias, Danieli, Alberto, Daumke, Oliver, Shi, Xiaoshan [u.v.m.], Su, Ming-Yuan, Sztacho, Martin, Trapannone, Riccardo, Turco, Eleonora, Witt, Marie   +9 more
core   +1 more source

A versatile toolbox for semi-automatic cell-by-cell object-based colocalization analysis

Scientific Reports, 2020
Differential fluorescence labeling and multi-fluorescence imaging followed by colocalization analysis is commonly used to investigate cellular heterogeneity in situ.
Anders Lunde, J. Glover
semanticscholar   +1 more source

Endocytosis and Endosomal Trafficking of DNA After Gene Electrotransfer In Vitro

Molecular Therapy: Nucleic Acids, 2016
DNA electrotransfer is a successful technique for gene delivery into cells and represents an attractive alternative to virus-based methods for clinical applications including gene therapy and DNA vaccination.
Christelle Rosazza, Hendrik Deschout, Annette Buntz, Kevin Braeckmans, Marie-Pierre Rols, Andreas Zumbusch   +5 more
doaj   +1 more source

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior [PDF]

, 2017
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V).
Barahona, María José, Elizondo Vega, Roberto, García Robles, María de los Ángeles, Martinez, Fernando, Millán, Carola, Ordenes, Patricio, Recabal, Antonia, Salgado, Magdiel, Sepúlveda, Fernando, Uranga, Romina Maria, Uribe, Elena   +10 more
core   +1 more source

Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy

Platelets, 2022
Interrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or ...
Hannah S. Heil, Max Aigner, Sophia Maier, Prateek Gupta, Luise M.C. Evers, Vanessa Göb, Charly Kusch, Mara Meub, Bernhard Nieswandt, David Stegner, Katrin G. Heinze   +10 more
doaj   +1 more source

Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines [PDF]

, 2017
Indexación: Web of Science; Scopus; Scielo.Background: Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale.
Cabana-Brunod, M, Fuentes, JA, Gonzalez-Nilo, FD, Llancalahuen, FM, Maldonado-Biermann, F, Marquez-Miranda, V, Otero, C, Penaloza, JP, Reyes-Ramirez, R, Rodriguez-Diaz, M, Velasquez, LA, Vilos, C   +11 more
core   +1 more source

A Thermodynamic Switch for Chromosome Colocalization [PDF]

Genetics, 2008
Abstract A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on thermodynamic grounds, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases
Nicodemi M, Panning B, Prisco A
openaire   +5 more sources

Single Lipid Molecule Dynamics on Supported Lipid Bilayers with Membrane Curvature

Membranes, 2017
The plasma membrane is a highly compartmentalized, dynamic material and this organization is essential for a wide variety of cellular processes. Nanoscale domains allow proteins to organize for cell signaling, endo- and exocytosis, and other essential ...
Philip P. Cheney, Alan W. Weisgerber, Alec M. Feuerbach, Michelle K. Knowles   +3 more
doaj   +1 more source

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Cell Reports, 2021
Summary: Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease ...
Matteo D’Antonio, Jennifer P. Nguyen, Timothy D. Arthur, Hiroko Matsui, Agnieszka D’Antonio-Chronowska, Kelly A. Frazer   +5 more
doaj   +1 more source