Results 41 to 50 of about 279,038 (339)

epiCOLOC: Integrating Large-Scale and Context-Dependent Epigenomics Features for Comprehensive Colocalization Analysis

Frontiers in Genetics, 2020
High-throughput genome-wide epigenomic assays, such as ChIP-seq, DNase-seq and ATAC-seq, have profiled a huge number of functional elements across numerous human tissues/cell types, which provide an unprecedented opportunity to interpret human genome and
Yao Zhou, Yongzheng Sun, Dandan Huang, Mulin Jun Li, Mulin Jun Li   +4 more
doaj   +1 more source

High-throughput multiparametric imaging flow cytometry: toward diffraction-limited sub-cellular detection and monitoring of sub-cellular processes

Cell Reports, 2021
Summary: We present a sheathless, microfluidic imaging flow cytometer that incorporates stroboscopic illumination for blur-free fluorescence detection at ultra-high analytical throughput.
Gregor Holzner, Bogdan Mateescu, Daniel van Leeuwen, Gea Cereghetti, Reinhard Dechant, Stavros Stavrakis, Andrew deMello   +6 more
doaj   +1 more source

Kerfuffle: a web tool for multi-species gene colocalization analysis [PDF]

, 2013
The evolutionary pressures that underlie the large-scale functional organization of the genome are not well understood in eukaryotes. Recent evidence suggests that functionally similar genes may colocalize (cluster) in the eukaryotic genome, suggesting ...
Aboukhalil, Robert, Atwal, Gurinder S., Fendler, Bernard   +2 more
core   +2 more sources

Editorial: Genomic Colocalization and Enrichment Analyses [PDF]

Frontiers in Genetics, 2021
To decipher the molecular basis of health and disease, profiling multiple molecular modalities is a common practice [e.g., genetic variation, transcription, chromatin accessibility, epigenomic marks, binding sites, and three dimensional (3D) genome architecture].
Chakravarthi Kanduri, Geir Kjetil Sandve, Eivind Hovig, Eivind Hovig, Subhajyoti De, Ryan M. Layer, Ryan M. Layer   +6 more
openaire   +3 more sources

EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms

Scientific Reports, 2018
Insight into the function and regulation of biological molecules can often be obtained by determining which cell structures and other molecules they localize with (i.e. colocalization).
Weston Stauffer, Huanjie Sheng, Han N. Lim   +2 more
semanticscholar   +1 more source

LocusFocus: Web-based colocalization for the annotation and functional follow-up of GWAS

PLoS Comput. Biol., 2020
Genome-wide association studies (GWAS) have primarily identified trait-associated loci in the non-coding genome. Colocalization analyses of SNP associations from GWAS with expression quantitative trait loci (eQTL) evidence enable the generation of ...
Naim Panjwani, Fan Wang, S. Mastromatteo, Allen Bao, Cheng Wang, Gengming He, Jiafen Gong, J. Rommens, Lei Sun, L. Strug   +9 more
semanticscholar   +1 more source

The cell cycle–apoptosis connection revisited in the adult brain [PDF]

, 2005
Adult neurogenesis is studied in vivo using thymidine analogues such as bromodeoxyuridine (BrdU) to label DNA synthesis during the S phase of the cell cycle.
Bauer, Sylvian, Patterson, Paul H.
core   +3 more sources

Genetic insights into the interaction between chronic hepatitis B virus infection and metabolic syndrome

Virulence
The association between chronic hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains controversial. We aimed to analyze the causal effects of chronic HBV infection on MetS components and vice versa.
Juanjuan Zou, Yijing Zhang, Xiaojing Sun, Yan Wang, Yanzhong Li, Ze-Hua Zhao   +5 more
doaj   +1 more source

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

Cell Genomics
Summary: Osteoarthritis (OA) poses a significant healthcare burden with limited treatment options. While genome-wide association studies (GWASs) have identified over 100 OA-associated loci, translating these findings into therapeutic targets remains ...
Nicole E. Kramer, Seyoun Byun, Philip Coryell, Susan D’Costa, Eliza Thulson, HyunAh Kim, Sylvie M. Parkus, Marielle L. Bond, Emma R. Klein, Jacqueline Shine, Susanna Chubinskaya, Michael I. Love, Karen L. Mohlke, Brian O. Diekman, Richard F. Loeser, Douglas H. Phanstiel   +15 more
doaj   +1 more source

Discovery of novel eGFR-associated multiple independent signals using a quasi-adaptive method

Frontiers in Genetics, 2022
A decreased estimated glomerular filtration rate (eGFR) leading to chronic kidney disease is a significant public health problem. Kidney function is a heritable trait, and recent application of genome-wide association studies (GWAS) successfully ...
Sahar Ghasemi, Sahar Ghasemi, Sahar Ghasemi, Tim Becker, Hans J. Grabe, Hans J. Grabe, Alexander Teumer, Alexander Teumer   +7 more
doaj   +1 more source