Results 51 to 60 of about 279,038 (339)

Diffusion-based DNA target colocalization by thermodynamic mechanisms

, 2010
In eukaryotic cell nuclei, a variety of DNA interactions with nuclear elements occur, which, in combination with intra- and inter- chromosomal cross-talks, shape a functional 3D architecture. In some cases they are organized by active, i.e. actin/myosin,
Augui, Berg, Berg, Berg, Binder, Chuang, Chubb, de Gennes, de Laat, de Laat, DeBell, Dekker, Doi, Donohoe, Dundr, Fraser, Galande, Gerland, Jing, Joanny, Kolomeisky, Kumar, Kumaran, Landau, Lanzuolo, Lassig, Lin, Lonard, Maerkl, Massie, Meaburn, Misteli, Misteli, Morozov, Nicodemi, Nicodemi, Nicodemi, Palstra, Quitschke, Renda, Scialdone, Semenov, Slutsky, Spudich, Stanley, Takizawa, von Hippel, Watson, Winter, Winter, Xu, Xu, Zhang, Zhao   +53 more
core   +1 more source

Localization of α-synuclein in teleost central nervous system: immunohistochemical and Western blot evidence by 3D5 monoclonal antibody in the common carp, Cyprinus carpio [PDF]

, 2015
Alpha synuclein (α-syn) is a 140 amino acid vertebrate-specific protein, highly expressed in the human nervous system and abnormally accumulated in Parkinson's disease and other neurodegenerative disorders, known as synucleinopathies.
CASINI, Arianna, CIONI, Carla, L. D’Este, S. Yu, TONI, MATTIA, VACCARO, Rosa, VIVACQUA, GIORGIO   +6 more
core   +1 more source

Genetic Pleiotropy and Causal Pathways Linking Glycemic Traits to Asthma: An Integrated Proteogenomic Investigation

Children
Background: While diabetes is a recognized risk factor for asthma, the shared genetic components between diabetes/glycemic traits and asthma remain unclear. This study investigates the genetic associations, causal relationships, and underlying mechanisms
Lin Chen, Juntao Lin, Yan Zhao, Guangli Zhang, Zhenxuan Kong, Chunlan Qiu, Kaicheng Peng, Hui Liu, Zhengxiu Luo   +8 more
doaj   +1 more source

A Novel In Silico Method for Molecular Mimicry Detection Finds a Formin with the Potential to Manipulate the Maize Cell Cytoskeleton

Molecular Plant-Microbe Interactions, 2021
Molecular mimicry is one of the evolutionary strategies that parasites use to manipulate the host metabolism and perform an effective infection. This phenomenon has been observed in several animal and plant pathosystems.
Vinicio Armijos-Jaramillo, Nicole Espinosa, Karla Vizcaíno, Daniela Santander-Gordón   +3 more
doaj   +1 more source

Actin cytoskeleton-dependent regulation of corticotropin-releasing factor receptor heteromers [PDF]

, 2017
Stress responses are highly nuanced and variable, but how this diversity is achieved by modulating receptor function is largely unknown. Corticotropin-releasing factor receptors (CRFRs), class B G protein–coupled receptors, are pivotal in mediating ...
Bhargava, Aditi, Burlingame, Alma, Chand, Shreya, Grammatopoulos, Dimitris K., Hasdemir, Burcu, Mahajan, Shilpi, Oses-Prieto, Juan, Woolley, Michael J.   +7 more
core   +1 more source

Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases

Cell Genomics
Summary: Crosstalk between N6-methyladenosine (m6A) and epigenomes is crucial for gene regulation, but its regulatory directionality and disease significance remain unclear.
Chengyu Li, Kexuan Chen, Qianchen Fang, Shaohui Shi, Jiuhong Nan, Jialin He, Yafei Yin, Xiaoyu Li, Jingyun Li, Lei Hou, Xinyang Hu, Manolis Kellis, Xikun Han, Xushen Xiong   +13 more
doaj   +1 more source

Cross-Talk-Free Multi-Color STORM Imaging Using a Single Fluorophore [PDF]

, 2014
Multi-color stochastic optical reconstruction microscopy (STORM) is routinely performed; however, the various approaches for achieving multiple colors have important caveats. Color cross-talk, limited availability of spectrally distinct fluorophores with
Borbely, Joseph Steven, Cordier, Guillaume Alan, Lakadamyali, Melike, Sandoval Alvarez, Angel, Tam, Johnny   +4 more
core   +3 more sources

Visualization of the exocyst complex dynamics at the plasma membrane of Arabidopsis thaliana [PDF]

, 2013
The exocyst complex, an effector of Rho and Rab GTPases, is believed to function as an exocytotic vesicle tether at the plasma membrane before soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex formation.
De Rycke, Riet, Drdová, Edita Janková, Fendrych, Matyáš, Nowack, Moritz, Pečenková, Tamara, Sekereš, Juraj, Synek, Lukáš, Žárský, Viktor   +7 more
core   +2 more sources

A Bayesian Framework for Multiple Trait Colocalization from Summary Association Statistics

bioRxiv, 2017
Most genetic variants implicated in complex diseases by genome-wide association studies (GWAS) are non-coding, making it challenging to understand the causative genes involved in disease. Integrating external information such as quantitative trait locus (
C. Giambartolomei, J. Liu, Wen Zhang, M. Hauberg, Huwenbo Shi, J. Boocock, Joseph K. Pickrell, A. Jaffe, The CommonMind Consortium, B. Pasaniuc, P. Roussos   +10 more
semanticscholar   +1 more source

A tessellation-based colocalization analysis approach for single-molecule localization microscopy

Nature Communications, 2019
Multicolor single-molecule localization microscopy (λSMLM) is a powerful technique to reveal the relative nanoscale organization and potential colocalization between different molecular species.
F. Levet, Guillaume Julien, R. Galland, C. Butler, A. Beghin, Anaël Chazeau, P. Hoess, J. Ries, Grégory Giannone, J. Sibarita   +9 more
semanticscholar   +1 more source