Results 61 to 70 of about 279,038 (339)

Anderson Photon-Phonon Colocalization in Certain Random Superlattices. [PDF]

Physical Review Letters, 2018
Fundamental observations in physics ranging from gravitational wave detection to laser cooling of a nanomechanical oscillator into its quantum ground state rely on the interaction between the optical and the mechanical degrees of freedom. A key parameter
G. Arregui, N. D. L. Kimura, C. S. Torres, P. Garc'ia   +3 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Insights Into Causal Effects of Genetically Proxied Lipids and Lipid‐Modifying Drug Targets on Cardiometabolic Diseases

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The differential impact of serum lipids and their targets for lipid modification on cardiometabolic disease risk is debated. This study used Mendelian randomization to investigate the causal relationships and underlying mechanisms.
Liwan Fu, Qin Liu, Hong Cheng, Xiaoyuan Zhao, Jingfan Xiong, Jie Mi   +5 more
doaj   +1 more source

CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans [PDF]

, 2019
Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy.
Buland, Justin R, Chou, Wendy Y. Y., Cole, F. Sessions, Dawson, Zachary, Homayouni, Airelle, Huang, Huiyan, Jia, Hanna, Kim, Hyori, Luke, Cliff J, Moreno, Marco, Pak, Stephen C, Silverman, Gary A, Thomas, Brian J, Wambach, Jennifer A, Wright, Ira E   +14 more
core   +3 more sources

Colocalizing subcategories and cosupport [PDF]

Journal für die reine und angewandte Mathematik (Crelles Journal), 2012
38 pages; minor changes; to appear in J. Reine.
Benson, Dave, Iyengar, Srikanth B., Krause, Henning   +2 more
openaire   +3 more sources

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Nature Communications, 2018
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,
N. Franceschini, C. Giambartolomei, P. D. de Vries, C. Finan, J. Bis, R. Huntley, R. Lovering, S. Tajuddin, T. Winkler, M. Graff, M. Kavousi, C. Dale, A. Smith, E. Hofer, E. V. van Leeuwen, I. Nolte, Lingyi Lu, M. Scholz, M. Sargurupremraj, N. Pitkänen, Oscar Franzén, P. Joshi, R. Noordam, R. Marioni, Shih-Jen Hwang, S. Musani, U. Schminke, W. Palmas, A. Isaacs, A. Correa, A. Zonderman, A. Hofman, A. Teumer, A. Cox, A. Uitterlinden, A. Wong, A. Smit, A. Newman, A. Britton, A. Ruusalepp, B. Sennblad, B. Hedblad, B. Pasaniuc, B. Penninx, C. Langefeld, C. Wassel, C. Tzourio, C. Fava, D. Baldassarre, D. O'leary, D. Teupser, D. Kuh, E. Tremoli, E. Mannarino, E. Grossi, E. Boerwinkle, E. Schadt, E. Ingelsson, F. Veglia, F. Rivadeneira, F. Beutner, G. Chauhan, G. Heiss, H. Snieder, H. Campbell, H. Völzke, H. Markus, I. Deary, J. Jukema, J. de Graaf, J. Price, Janne Pott, J. Hopewell, Jingjing Liang, J. Thiery, J. Engmann, K. Gertow, K. Rice, K. Taylor, K. Dhana, L. Kiemeney, L. Lind, L. Raffield, L. Launer, L. Holdt, M. Dörr, M. Dichgans, M. Traylor, M. Sitzer, M. Kumari, M. Kivimaki, M. Nalls, O. Melander, O. Raitakari, O. Franco, O. Rueda-Ochoa, Panagiotis Roussos, P. Whincup, P. Amouyel, P. Giral, Pramod Anugu, Q. Wong, R. Malik, R. Rauramaa, R. Burkhardt, R. Hardy, R. Schmidt, R. de Mutsert, R. Morris, R. Strawbridge, S. Wannamethee, S. Hägg, Sonia H. Shah, S. McLachlan, S. Trompet, S. Seshadri, S. Kurl, S. Heckbert, S. Ring, T. Harris, T. Lehtimäki, T. Galesloot, T. Shah, U. de Faire, V. Plagnol, W. Rosamond, W. Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Y. Saba, Yukinori Aniket Loes Anne-Katrin Sander W. Solveig Christop Okada Mishra Rutten-Jacobs Giese van der Laan Gret, Y. Okada, A. Mishra, L. Rutten-Jacobs, A. Giese, S. W. van der Laan, S. Gretarsdottir, C. Anderson, M. Chong, H. Adams, T. Ago, P. Almgren, P. Amouyel, H. Ay, Traci M. Bartz, O. Benavente, S. Bevan, G. Boncoraglio, Robert D. Brown, A. Butterworth, C. Carrera, C. Carty, D. Chasman, Wei-Min Chen, J. Cole, Ioana Cotlarciuc, Carlos Cruchaga, J. Danesh, P. D. de Bakker, A. Destefano, M. den Hoed, Qing Duan, S. Engelter, G. Falcone, R. Gottesman, R. Grewal, S. Gustafsson, J. Haessler, Ahamad Hassan, A. Havulinna, E. Holliday, G. Howard, F. Hsu, H. Hyacinth, M. Ikram, M. Irvin, X. Jian, J. Jiménez-Conde, Julie A. Johnson, J. Jukema, M. Kanai, Keith L. Keene, B. Kissela, D. Kleindorfer, C. Kooperberg, M. Kubo, L. Lange, C. Langefeld, C. Langenberg, J. Lee, R. Lemmens, D. Leys, C. Lewis, Wei-Yu Lin, A. Lindgren, E. Lorentzen, P. Magnusson, J. Maguire, A. Manichaikul, P. McArdle, J. Meschia, T. Mosley, T. Ninomiya, M. O’Donnell, S. Pulit, Kristiina Rannikmäe, A. Reiner, K. Rexrode, S. Rich, P. Ridker, N. Rost, P. Rothwell, T. Rundek, R. Sacco, S. Sakaue, M. Sale, V. Salomaa, B. Sapkota, R. Schmidt, C. Schmidt, U. Schminke, Pankaj Sharma, A. Słowik, C. Sudlow, C. Tanislav, T. Tatlisumak, V. Thijs, G. Thorleifsson, U. Thorsteinsdóttir, S. Tiedt, M. Walters, N. Wareham, S. Wassertheil-Smoller, K. Wiggins, Qiong Yang, S. Yusuf, T. Pastinen, E. Schadt, Simon Koplev, Veronica Codoni, M. Civelek, Nick Smith, D. Trégouët, I. Christophersen, C. Roselli, S. Lubitz, P. Ellinor, E. Tai, J. Kooner, N. Kato, Jiang He, P. van der Harst, P. Elliott, J. Chambers, F. Takeuchi, Andrew D. Johnson, D. Sanghera, C. Jern, D. Strbian, I. Férnandez-Cadenas, W. Longstreth, A. Rolfs, J. Hata, D. Woo, J. Rosand, G. Paré, D. Saleheen, K. Stefánsson, B. Worrall, S. Kittner, J. Howson, Y. Kamatani, A. Dehghan, A. Seldenrijk, A. Morrison, A. Hamsten, B. Psaty, C. V. van Duijn, D. Lawlor, D. Mook-Kanamori, D. Bowden, H. Schmidt, James F. Wilson, James G. Wilson, J. Rotter, J. Wardlaw, J. Deanfield, J. Halcox, L. Lyytikäinen, M. Loeffler, M. Evans, S. Debette, S. Humphries, U. Völker, V. Gudnason, A. Hingorani, J. Björkegren, J. Casas, C. O’Donnell   +299 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Bordetella parapertussis Survives inside Human Macrophages in Lipid Raft-Enriched Phagosomes [PDF]

, 2014
Bordetella parapertussis is a human pathogen that causes whooping cough. The increasing incidence of B. parapertussis has been attributed to the lack of cross protection induced by pertussis vaccines. It was previously shown that B. parapertussis is able
Gorgojo, Juan Pablo, Harvill, Eric, Rodriguez, Maria Eugenia   +2 more
core   +3 more sources

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Nature Genetics, 2015
Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions, finding major pathways contributing to risk, with some loci shared across immune disorders.
Suna Onengut-Gumuscu, Wei-Min Chen, O. Burren, N. Cooper, A. Quinlan, J. Mychaleckyj, Emily Farber, J. Bonnie, M. Szpak, E. Schofield, P. Achuthan, Hui Guo, M. Fortune, H. Stevens, N. Walker, L. D. Ward, Anshul B Kundaje, Manolis Kellis, M. Daly, J. Barrett, J. Cooper, P. Deloukas, J. Todd, C. Wallace, P. Concannon, S. Rich   +25 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source