Results 141 to 150 of about 1,737,210 (406)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Journal of the American Medical Association, 1912 A study of the conditions affecting the lower right side of the abdomen has resulted in the acquisition of much valuable knowledge. This knowledge has not been acquired all at once, but, as is usual, it has come slowly and only after much labor. It is a curious fact, too, that here, as in so many other instances in the history of medicine, thought has ...
openaire +3 more sources
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Nature Genetics, 2008 For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of oncogenes and hypermethylation of tumor suppressor genes.
R. Irizarry +13 more
semanticscholar +1 more source
Comparison of three with six regions of interest analyses in patients with idiopathic constipation undertaking colon transit scintigraphy using 67Ga-citrate [PDF]
, 2013 OBJECTIVE AND INTRODUCTION: Preparation of data from 6 geometric regions of interest in the colon is time consuming, and can become impractical in the environment of busy Nuclear Medicine Departments.
Asli, I.N. +5 more
core
Euclidean Hypersurfaces with Genuine Conformal Deformations in Codimension Two [PDF]
arXiv, 2018 In this paper we classify Euclidean hypersurfaces $f\colon M^n \rightarrow \mathbb{R}^{n+1}$ with a principal curvature of multiplicity $n-2$ that admit a genuine conformal deformation $\tilde{f}\colon M^n \rightarrow \mathbb{R}^{n+2}$. That $\tilde{f}\colon M^n \rightarrow \mathbb{R}^{n+2}$ is a genuine conformal deformation of $f$ means that it is a ...
arxiv
Scientific ReportsOptimal management of T1 colorectal cancer (CRC) remains controversial. This study compared the long-term outcomes of endoscopic resection with additional surgical resection (ER + ASR) versus primary surgical resection (PS) in patients with T1 CRC and ...
Pin-Chun Chen +4 more
doaj +1 more source
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source