Results 21 to 30 of about 604,873 (268)

An Observational Study of Trifluridine/Tipiracil-Containing Regimen Versus Regorafenib-Containing Regimen in Patients With Metastatic Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundThere are no randomized control trials comparing the efficacy of trifluridine/tipiracil and regorafenib in patients with metastatic colorectal cancer (mCRC).
Meng-Che Hsieh, Meng-Che Hsieh, Kun-Ming Rau, Kun-Ming Rau, Shung-Eing Lin, Shung-Eing Lin, Kuang-Wen Liu, Kuang-Wen Liu, Chong-Chi Chiu, Chong-Chi Chiu, Chih-I Chen, Chih-I Chen, Ling-Chiao Song, Ling-Chiao Song, Hsin-Pao Chen, Hsin-Pao Chen   +15 more
doaj   +1 more source

Colonic tuberculosis masquerading as colon cancer [PDF]

Journal of Surgical Case Reports, 2012
Isolated colonic tuberculosis (TB) is rare, and the symptoms are nonspecific making early diagnosis and management difficult. Although colonoscopy and biopsy is an important diagnostic modality, the features are variable and the distinction from other conditions of the colon, especially Crohn's disease and cancer, may be impossible without surgical ...
Kumar, A, Patodia, M, Pandove, PK, Sharda, VK   +3 more
openaire   +2 more sources

Impact of adherence to board‐certified surgeon systems and clinical practice guidelines on colon cancer surgical outcomes in Japan: A questionnaire survey of the National Clinical Database

Annals of Gastroenterological Surgery, 2020
Aim To investigate the effectiveness of the institutional medical structure and of the implemented clinical practice guidelines for improving colon cancer surgical outcomes.
Hirotoshi Kobayashi, Hiroyuki Yamamoto, Hiroaki Miyata, Mitsukazu Gotoh, Kenjiro Kotake, Kenichi Sugihara, Yasushi Toh, Yoshihiro Kakeji, Yasuyuki Seto   +8 more
doaj   +1 more source

Predictive biomarkers of colon cancer immunotherapy: Present and future

Frontiers in Immunology, 2022
Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors (ICIs) have shown clinical benefits for colon cancer patients, especially those with high microsatellite instability (MSI-H).
Wanting Hou, Cheng Yi, Hong Zhu
doaj   +1 more source

Carotenoids and colon cancer [PDF]

The American Journal of Clinical Nutrition, 2000
Carotenoids have numerous biological properties that may underpin a role for them as chemopreventive agents. However, except for beta-carotene, little is known about how dietary carotenoids are associated with common cancers, including colon cancer.The objective of this study was to evaluate associations between dietary alpha-carotene, beta-carotene ...
M L, Slattery, J, Benson, K, Curtin, K N, Ma, D, Schaeffer, J D, Potter   +5 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Short-term and long-term outcomes after robotic radical surgery for rectal gastrointestinal stromal tumor

BMC Surgery
Background The optimal approach for ensuring both complete resection and preservation of anal function in rectal gastrointestinal stromal tumor (GIST) remains unknown.
Chikara Maeda, Yusuke Yamaoka, Akio Shiomi, Hiroyasu Kagawa, Hitoshi Hino, Shoichi Manabe, Chen Kai, Kenji Nanishi   +7 more
doaj   +1 more source

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Cancer Medicine, 2019
Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs.
Hitoshi Hino, Akio Shiomi, Masatoshi Kusuhara, Hiroyasu Kagawa, Yushi Yamakawa, Keiichi Hatakeyama, Takanori Kawabata, Takuma Oishi, Kenichi Urakami, Takeshi Nagashima, Yusuke Kinugasa, Ken Yamaguchi   +11 more
doaj   +1 more source

IRF4 overexpression promotes the transdifferentiation of tregs into macrophage‐like cells to inhibit the development of colon cancer

Cancer Cell International, 2021
Background Interferon regulatory factor 4 (IRF4) is a transcription factor from the IRF factor family that exerts regulatory functions in the immune system and oncogenesis. However, the biological role of IRF4 in colon cancer is still unclear. The aim of
Jiwei Wang, Song Li, Honglang Li, Xiaoshuang Zhou, Huabin Wen, Bin Lai   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source