Results 31 to 40 of about 1,397,746 (291)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

From Garrisoned District to Chinese Town: Land and Boundaries at the Kowloon Walled City, 1898-1912

open access: yesArchitectural Histories, 2022
The Kowloon Walled City in Hong Kong became a named entity around 1810 and was demolished in 1994, but its architecture had long been unclassified. Not until the years just prior to its demolition did this dense slum of informal multi-story buildings ...
Y. L. Lucy Wang
doaj   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Acuphagia on the Obsessive-Compulsive Spectrum in an Adolescent Male

open access: yesCase Reports in Psychiatry, 2020
Background. Pica is a condition that is commonly missed in childhood. This condition occurs worldwide and is considered normal in children from ages 18- to- 36 months. It is also commonly seen in pregnant women due to associated nutritional deficiencies.
William Butler, Luis Allen
doaj   +1 more source

Settler colonialism, multiculturalism and the politics of postcolonial identity [PDF]

open access: yes, 2015
The twentieth century saw the development of nationalism and the construction of postcolonial identities in many newly independent nations. Formerly colonised peoples have struggled to restore and adapt their customs and to construct postcolonial ...
Lovell, Melissa
core  

Urban football narratives and the colonial process in Lourenço Marques [PDF]

open access: yes, 2011
Support for Portuguese football teams, in Mozambique as well as in other former Portuguese colonies, could be interpreted either as a sign of the importance of a cultural colonial heritage in Africa or as a symbol of a perverse and neo-colonial ...
Alegi Peter.   +20 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Antipodean Intimacies: Medical Sex Advice for Women in the Australian colonies, 1857-1890 [PDF]

open access: yes, 2007
This article examines a genre of medical sex advice literature that emerged in colonial Australia at the close of the 19th century. While historians have examined medical discourse as a site for the production of raced bodies, this article points out ...
Samia Khatun
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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