Results 31 to 40 of about 1,403,065 (291)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

From Garrisoned District to Chinese Town: Land and Boundaries at the Kowloon Walled City, 1898-1912

Architectural Histories, 2022
The Kowloon Walled City in Hong Kong became a named entity around 1810 and was demolished in 1994, but its architecture had long been unclassified. Not until the years just prior to its demolition did this dense slum of informal multi-story buildings ...
Y. L. Lucy Wang
doaj   +2 more sources

The Colonial Official as Ethnographer; VOC Documents as Resources for Social History in Eastern Indonesia [PDF]

, 2012
The present article departs from the inherent problems of grasping the voice of the subaltern other in a colonial context. While postcolonial theoreticians have occasionally spoken pessimistically about the possibilities of reconstructing the agency of ...
Hägerdal, H. (Hans)
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Enlightenment, Latin America, Age of Revolutions, Spanish America, Brazil [PDF]

, 2017
An essay analyzing the effect of Enlightenment thinking on the political and societal elite of the colonial Spanish and Portuguese Americas, and the subsequent colonial ...
Lentz, Katherine A.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Acuphagia on the Obsessive-Compulsive Spectrum in an Adolescent Male

Case Reports in Psychiatry, 2020
Background. Pica is a condition that is commonly missed in childhood. This condition occurs worldwide and is considered normal in children from ages 18- to- 36 months. It is also commonly seen in pregnant women due to associated nutritional deficiencies.
William Butler, Luis Allen
doaj   +1 more source

Remembering and belonging : colonial settlers in New Zealand museums : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Anthropology at Massey University [PDF]

, 2007
This study approaches museums as socially constructed signifiers of group identities. Focusing specifically on museological representations of colonial settlers at museums and historical sites in New Zealand, I analyse how this group is constructed in ...
Wirick, Esther Lucia
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source