Results 51 to 60 of about 79,968 (214)
GrafíaDurante el siglo XVII, la muerte ocupó un papel principal en los discursos que impartía la Iglesia católica en Santafé. Contando con una población que, en su mayoría, no leía ni escribía el castellano, las pinturas fueron una herramienta clave para la ...
Laura Vivian Martínez Benítez
doaj
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
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Voces conventuales: escritura y autoría femenina en Hispanoamérica (Siglos XVII- XVIII)
Fronteras de la Historia, 2022 Jimena Guerrero Ramírez
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
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HISTOReLo: Revista de Historia Regional y Local, 2017 La Gobernación del Tolima ha ejercido labores en cuatro edificios que han implicado la demolición de su predecesor. Estudiar las causas de estas transformaciones y su significado fue el propósito de esta investigación. En relación con sus características
Andrés Ernesto Francel Delgado
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
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Le passé indéfini : du « précolonial » en Afrique subsaharienne
Les Nouvelles de l’Archéologie, 2011 Empirically convenient, apparently clear, the concept of "pre-colonialisation" has been long talked about, despite its distinct uses and uncertain limits, encompassing a large scale of time between several millennia to the nineteenth century.
Alexandra Galitzine-Loumpet
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
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Antipodean and Biblical Encounter: Postcolonial Vernacular Hermeneutics in Novel Form
Religions, 2019 This article argues that in postcolonial and post-secular Australia, a country in which Christianity has been imported from Europe in the process of colonization in the eighteenth century by the British Empire, institutional Christianity is waning in ...
Michele A. Connolly
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