Results 51 to 60 of about 368,777 (299)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Institutional Development and Colonial Heritage within Brazil [PDF]
This paper analyzes the determinants of local institutions and distribution of political power within a constant 'macro-institutional' setting. We show that characteristics of Brazilian municipalities related to institutional quality and distribution of ...
Assunção, Juliano J. +2 more
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Mercado interno versus mercado colonial en la primera industrialización española [PDF]
, 1995 Editada en Fundación Empresa PúblicaLa intención de este ensayo es analizar el papel del mercado hispanoamericano en el desarrollo de la industria española durante la segunda mitad del siglo XVIII.
Delgado Ribas, Josep María
core
Legal origin, colonial origin and deforestation [PDF]
This paper investigates whether inherited legacies such as legal origin allow of explaining deforestation in 110 developed and developing countries. The hypothesis is that differences in deforestation between countries can be attributed to their legal ...
Sébastien Marchand
core +2 more sources
Voces conventuales: escritura y autoría femenina en Hispanoamérica (Siglos XVII- XVIII)
Fronteras de la Historia, 2022 Jimena Guerrero Ramírez
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
GrafíaDurante el siglo XVII, la muerte ocupó un papel principal en los discursos que impartía la Iglesia católica en Santafé. Contando con una población que, en su mayoría, no leía ni escribía el castellano, las pinturas fueron una herramienta clave para la ...
Laura Vivian Martínez Benítez
doaj