Results 71 to 80 of about 368,777 (299)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Maps, fields, and boundary cairns: demarcation and resistance in colonial Cyprus [PDF]

, 2002
An important component of the administration and control of a colony by an external power was the demarcation and classification of the land and its people.
Given, M.
core   +1 more source

Colonial Voice Reinterpreted: A Readers Theatre Presentation

eTropic: electronic journal of studies in the tropics, 2011
Father and daughter inhabit the same space but interpret it differently. A colonial and a present-day educator see Papua New Guinea life through new lenses - the curriculum and the academic goals; students with new ambitions and diverse lifestyle issues;
Jillian Thiele, David Thiele
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Did the Colonial Powers Pick Economic Winners? [PDF]

This paper proposes a new instrument for institutional quality—-the salary of colonial governors—-to investigate whether variations in the quality of British colonial rule continue to have an impact on the economic performance of former colonies ...
Jones, Patricia
core  

The colonial development of concentration camps (1868–1902) [PDF]

, 2011
The forced labour and extermination camps established in Europe during the Second World War gave the meaning to the term 'concentration camp' which it has for the general public today.
Iain R. Smith, Andreas Stucki, Stucki, Andreas, Smith, Iain R.   +3 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

D'Alberti Papers, vol. 12, 1801-1802 (Correspondence, incoming and outgoing, between the Colonial Office and the Governor's Office in Newfoundland)

This 34 volume set contains typewritten copies of handwritten transcripts of Newfoundland material obtained from the Colonial Office Records in the Public Record Office, London, covering incoming and outgoing correspondence between the Colonial Office ...
Great Britain. Colonial Office.
core  

Colonies with position

Comput. Artif. Intell., 1996
Summary: A new type of grammar colony is introduced. Its individual components have some features of recognizing machines, nevertheless it is a generative system. The name `colonies with position' is proposed for it. The class \({\mathcal L}_{col_P (1)}\) of languages generated by a single component, as well as the class generated by colonies of such ...
openaire   +2 more sources