Results 61 to 70 of about 1,383,550 (260)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Colony entropy - Allocation of goods in ant colonies

PLOS Computational Biology, 2019
Abstract Allocation of goods is a key feature in defining the connection between the individual and the collective scale in any society. Both the process by which goods are to be distributed, and the resulting allocation to the members of the society may affect the success of the population as a whole. One of the most
Greenwald, Efrat, Eckmann, Jean-Pierre, Feinerman, Ofer   +2 more
openaire   +5 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Public records in Colonial Maryland [PDF]

, 1974
Historical analysis of the efforts to create, maintain, and use the records of the administration of the colony of ...
Cox, RJ
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Is Video-Conferencing Helpful for Physical Education Classes in the New Normal? A PLS-SEM Analysis Adopting the Technology Acceptance Model

Journal of Learning for Development
Research shows that videoconferencing tools can be used for delivering high-quality instruction in real-time to a large number of students simultaneously during and even in the aftermath of the pandemic.
Joseph Lobo, Francisco Gabriel Prevandos, Jem Cloyd Tanucan, Edi Setiawan   +3 more
doaj   +1 more source

Civilisation, settlers and wanderers: Law, politics and mobility in nineteenth century New Zealand and Australia [PDF]

, 2011
Mobility was constitutive of the 19th century British colonial period in the Pacific. The circulation of capital and commodities, technologies of transportation and communication, travelling ideologies and systems of governance and surveillance, as well ...
Seuffert, Nan
core   +2 more sources

Book Review: Was Hinduism Invented? : Britons, Indians, and Colonial Construction of Religion [PDF]

, 2007
A review of Was Hinduism Invented?
Fort, Andrew O.
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

La historia como realidad y ficción: los distintos mundos de El hombre en el castillo

Norteamérica, 2018
Se analiza la serie televisiva de El hombre en el castillo, una ucronía inspirada en la novela homónima de ciencia ficción de Philip K. Dick, donde se plantea una historia alternativa en la que Alemania y Japón han ganado la segunda guerra mundial a los
Nelson Arteaga Botello
doaj   +1 more source