Results 41 to 50 of about 79,968 (214)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
“¡España es también aquí!”: Nación e imaginario colonial en los cuentos de Emilia Pardo Bazán
Castilla: Estudios de Literatura, 2018 En el contexto de la biopolítica imperialista del siglo XIX, la guerra en Cuba y Filipinas supuso para España el cuestionamiento definitivo de su vigor racial y un replanteamiento de su configuración nacional. Emilia Pardo Bazán fue una de las plumas que
Susana Bardavío Estevan
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Journal of Learning for DevelopmentResearch shows that videoconferencing tools can be used for delivering high-quality instruction in real-time to a large number of students simultaneously during and even in the aftermath of the pandemic.
Joseph Lobo +3 more
doaj +1 more source
At Home with Durga: The Goddess in a Palace and Corporeal Identity in Rituparno Ghosh’s Utsab
Religions, 2014 In this article, I examine the representational strategies used to visualize the pratima (deity) of the Hindu goddess, Durga, as a paradigm of time, memory, and corporeal identity, in Rituparno Ghosh’s 2000 Bengali film Utsab.
Romita Ray
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
History and environment of Yucatan in the sixteenth century
Logos Ciencia & Tecnología, 2016 The history of natural resources has transcendental problems such as environmental degradation and usefulness of trace their past as well as production units and the forms of appropriation of the landscape arises.
Bolio Ortíz, Juan Pablo +2 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source