Results 111 to 120 of about 90,261 (311)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity

, 2006
BACKGROUND: Factors determining the extension and degree of inflammation in the colonic mucosa of patients with ulcerative colitis (UC) are largely unknown, but CD4+CD25high regulatory T cells (Tregs) have been implicated to play an important role in ...
Holmén, Nathalie,, Lundgren, Anna,, Lundin, Samuel B,, Bergin, Ann-Marie,, Rudin, Anna,, Sjövall, Henrik,, Öhman, Lena,   +6 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The Effect of Probiotic Yogurt on Controlling the Symptoms of Irritable Bowel Syndrome [PDF]

Background & Objectives: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is common through the world including Iran. Because of its chronic nature and lack of effective treatment, patients are always anxious and stressful ...
انتشاری مقدم, افسانه, تذکری, زهرا, میرزا رحیمی, مهرداد, پورفرضی, فرهاد, فرزانه, اسماعیل, یزدانبد, عباس   +5 more
core  

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Effect of diet type on serum and faecal concentration of S100/calgranulins in the captive cheetah

, 2014
Gastrointestinal disease is omnipresent in captive cheetahs (Acinonyx jubatus), in contrast to its freeranging populations. The current study aimed to evaluate the effect of diet type (meat-only whole prey) on gastrointestinal health in captive cheetahs ...
Depauw, S, Heilmann, RM, Hesta, M, Whitehouse-Tedd, K, Steiner, JM, Janssens, GPJ, Suchodolski, JS   +6 more
core  

A Molecular Shielding Strategy to Develop Low Protein Binding, Renal Clearable Pan‐Cancer Near‐Infrared Probes

Advanced Functional Materials, EarlyView.
A molecular shielding strategy to convert “protein‐sticky” and “non‐tumor specific” clinical ICG dye, into a “low protein binding” and “tumor‐targeting” dye with prolonged blood circulation and renal clearance is described. These shielded ICGs demonstrate strong tumor accumulation and optimal tissue clearance, resulting in high tumor‐to‐background ...
Li Xiang, Kailin Mooney, Mingchong Dai, Morgan R. Stewart, Samantha Holland, Michael I. Henderson, Samuel Drennan, Ramon F. Barajas Jr., Jared M. Fischer, Adem Yildirim   +9 more
wiley   +1 more source

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation

, 2015
The authors acknowledge the support of the Biotechnology and Biological Sciences Research Council (BBSRC), this research was partly funded by the BBSRC Institute Strategic Programme for The Gut Health and Food Safety (BB/J004529/1) and by the BB/L008602 ...
Vos, W.M., de, Hardy-Goddard, Jemma, Crost, Emmanuelle H., de Vos, Willem M., Gall, G., Le, Taylor, Garry L., Walshaw, J., Tailford, L.E., Crost, E.H., Taylor, G.L., Juge, N., Owen, C.D., Tailford, Louise E., Owen, C. David, Le Gall, G., Le Gall, Gwenaelle, Hardy-Goddard, J., Juge, Nathalie, Walshaw, John, de Vos, W.M.   +19 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source