Results 41 to 50 of about 90,261 (311)

Significance of Ligand-Anchored Polymers for Drug Targeting in the Treatment of Colonic Disorders

Frontiers in Pharmacology, 2020
Treatment of a variety of bowel diseases like Crohn’s disease, ulcerative colitis, colonic cancers, colonic pathologies, and systemic delivery of drugs at the target sites can be done with the help of targeted drug delivery technique.
Pramila Chaubey, Munira Momin, Sujata Sawarkar   +2 more
doaj   +1 more source

Identification of colorectal cancer related genes with mRMR and shortest path in protein-protein interaction network. [PDF]

PLoS ONE, 2012
One of the most important and challenging problems in biomedicine and genomics is how to identify the disease genes. In this study, we developed a computational method to identify colorectal cancer-related genes based on (i) the gene expression profiles,
Bi-Qing Li, Tao Huang, Lei Liu, Yu-Dong Cai, Kuo-Chen Chou   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The role of rectal hyposensitivity in the development of functional hindgut disorders: clinical significance and pathophysiology [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorBackground Rectal hyposensitivity (RH) is associated with functional hindgut ...
Burgell, Rebecca Elizabeth
core  

Functional and physiologic assessment of the colonic reservoir or side-to-end anastomosis after low anterior resection for rectal cancer : a two-year follow-up

, 2005
Purpose: Functional disturbances are common after anterior resection for rectal cancer. This study was designed to compare functional and physiologic outcome after low anterior resection and total mesorectal excision with a colonic J-pouch or a side-to ...
Nygren, Jonas,, Goldman, Sven,, Machado, Mikael,, Ljungqvist, Olle,   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Colonic structural and functional relationships in health and inflammation [PDF]

, 1998
In health colonic function includes fluid and electrolyte salvage to produce dehydrated, formed stools. Effective salvage requires the removal of luminal sodium against considerable electrochemical and concentration gradients.
Menon, Rachel Anne
core  

A Study on the Relationship between Dietary Patterns and Prevalence of Irritable Bowel Syndrome

پزشکی بالینی ابن سینا, 2015
Introduction & Objective: Although several dietary factors have been reported to alleviate or ag-gravate the symptoms of irritable bowel syndrome (IBS), no information is available linking dietary patterns to irritable bowel syndrome.
Omid Sadeghi, Seyyed Saeed Khayyatzadeh, Ahmad Esmaillzadeh, Ammar Hasanzadeh Keshteli, Peyman Adibi   +4 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Autologous cell transplantation for treatment of colorectal aganglionosis in mice

Nature Communications
Neurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the enteric nervous system (ENS) in a model of ...
Weikang Pan, Ahmed A. Rahman, Takahiro Ohkura, Rhian Stavely, Kensuke Ohishi, Christopher Y. Han, Abigail Leavitt, Aki Kashiwagi, Alan J. Burns, Allan M. Goldstein, Ryo Hotta   +10 more
doaj   +1 more source