Results 31 to 40 of about 90,261 (311)

Metabolism of Phenolics of Tetrastigma hemsleyanum Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats

Foods, 2021
Tetrastigma hemsleyanum Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The Tetrastigma hemsleyanum root (THR) has been prevalently consumed as a functional tea or dietary supplement.
Yong Sun, Fanghua Guo, Xin Peng, Kejun Cheng, Lu Xiao, Hua Zhang, Hongyan Li, Li Jiang, Zeyuan Deng   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases

, 2007
BACKGROUND: Leukotrienes derived from the 5-lipoxygenase pathway are proinflammatory lipid mediators that possibly play a role in inflammatory bowel diseases.
Hillier, Keith, Penrose, John F., Cazaly, Angelica M., Sampson, Anthony P., Johnson, Penny A., Jupp, James, Elliott, Daniel H., Fine, David R., Bateman, Adrian C.   +8 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Functional analysis of colonic bacterial metabolism: relevant to health?

, 2012
With the use of molecular techniques, numerous studies have evaluated the composition of the intestinal microbiota in health and disease. However, it is of major interest to supplement this with a functional analysis of the microbiota.
Henrike M. Hamer, Kristin Verbeke, Karen Windey, Vicky De Preter   +3 more
core   +1 more source

In vitro screening of probiotic lactic acid bacteria and prebiotic glucooligosaccharides to select effective synbiotics [PDF]

, 2010
Probiotics and prebiotics have been demonstrated to positively modulate the intestinal microflora and could promote host health. Although some studies have been performed on combinations of probiotics and prebiotics, constituting synbiotics, results on ...
Julien Grimoud, Durand, Henri, Henri Durand, Monsan, Pierre, Courtin, Céline, Grimoud, Julien, Theodorou, Vassilia, Christine Roques, Pierre Monsan, Françoise Ouarné, Ouarné, Françoise, Céline Courtin, Roques, Christine, Rogues, Christine, Vassilia Theodorou   +14 more
core   +1 more source

Colonic delivery of metronidazole-loaded capsules for local treatment of bacterial infections: a clinical pharmacoscintigraphy study

, 2021
Drug delivery to the colon offers great promise for local treatment of colonic diseases as it allows bypassing systemic absorption in the small intestine, thereby increasing luminal drug concentrations in the colon.
Bravo, Roberto, Caobelli, Federico, Puchkov, Maxim, Spleiss, Johannes, Hartig, Claudia, Wild, Damian, Huwyler, Jörg, Preisig, Daniel, Abbes, Sonia, Varum, Felipe, Haschke, Manuel   +10 more
core   +1 more source

Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine

Frontiers in Cell and Developmental Biology, 2022
Vimentin has been implicated in wound healing, inflammation, and cancer, but its functional contribution to intestinal diseases is poorly understood.
Linglu Wang, Ponnuswamy Mohanasundaram, Michelle Lindström, Muhammad Nadeem Asghar, Giulia Sultana, Julia O. Misiorek, Julia O. Misiorek, Yaming Jiu, Yaming Jiu, Hongbo Chen, Zhi Chen, Diana M. Toivola, Diana M. Toivola, Diana M. Toivola, Fang Cheng, John E. Eriksson, John E. Eriksson   +16 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The long-term consequences of antibiotic therapy: Role of colonic short-chain fatty acids (SCFA) system and intestinal barrier integrity.

PLoS ONE, 2019
Epidemiological studies revealed that antibiotics exposure increases a risk of inflammatory bowel diseases (IBD) development. It remained largely unknown how antibiotic-induced dysbiosis confers the risk for enhanced inflammatory response. The aim of the
Yuliia Holota, Taisa Dovbynchuk, Izumi Kaji, Igor Vareniuk, Natalia Dzyubenko, Tetiana Chervinska, Liudmyla Zakordonets, Viktoria Stetska, Liudmyla Ostapchenko, Tetiana Serhiychuk, Ganna Tolstanova   +10 more
doaj   +1 more source