Results 81 to 90 of about 134,474 (309)
A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome : results from a randomized double-blind placebo-controlled pilot trial [PDF]
, 2017 Background: Constipation and symptoms of gastrointestinal discomfort such as bloating are common among otherwise healthy individuals, but with significant impact on quality of life.
Marzorati, Massimo +6 more
core +1 more source
Study on function of aganglionic colon musculature of hirschsprung's disease murine model.
Japanese Journal of Smooth Muscle Research, 1990 This study examined the function in vitro of aganglionic colon musculature in mice with hereditary aganglionosis--a strain of animals used as a model of Hirschsprung's disease. Double sucrose gap recordings from the muscle strips of both normal and aganglionic colon showed bursts of spike potentials with muscle contraction.
T, Okasora +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Fecal calprotectin concentration in the differential diagnosis of bowel diseases
Терапевтический архив, 2015 Aim. To estimate the informative value of a noninvasive fecal (calprotectin) test in the differential diagnosis of bowel diseases. Subjects and methods.
M F Osipenko +3 more
doaj
Ecotoxicology and Environmental SafetyBackground: Di-n-pentyl phthalate (DnPP), a ubiquitous plasticizer structurally analogous to the gut toxicant di-(2-ethylhexyl) phthalate (DEHP), poses environmental persistence and human exposure risks, yet its gastrointestinal toxicity remains poorly ...
Yanyouhong Liu +15 more
doaj +1 more source
Cells, 2019 Different gastrointestinal disorders, including inflammatory bowel diseases (IBD), have been linked to alterations of the gut microbiota composition, namely dysbiosis.
Claudia Burrello +10 more
doaj +1 more source
Practice parameters for the treatment of colonic diverticular disease: Italian Society of Colon and Rectal Surgery (SICCR) guidelines [PDF]
, 2015 The mission of the Italian Society of Colorectal Surgery (SICCR) is to optimize patient care. Providing evidence-based practice guidelines is therefore of key importance.
Annibale, Bruno +7 more
core +2 more sources
Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics
The Journal of Physiology, 2012 Abstract Intestinal barrier dysfunction is a main feature of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Leak flux diarrhoea and a facilitated uptake of noxious antigens are the two consequences resulting from an impaired epithelial barrier.
Nina A, Hering +2 more
openaire +3 more sources
Comparison of bran, ispaghula, and lactulose on colon function in diverticular disease. [PDF]
Gut, 1978 Bran, ispaghula (Fybogel), and lactulose were given to three groups of patients with diverticular disease for four weeks. Faecal weights, bile acids, fat and electrolytes, transit time, and colonic motility were estimated before and after treatment. Stool weight increased, notably with Fybogel.
M A, Eastwood +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source