Results 61 to 70 of about 180,158 (258)

The Interaction of Large Bowel Microflora with the Colonic Mucus Barrier

International Journal of Inflammation, 2010
The colonic mucus barrier is the first line of defence that the underlying mucosa has against the wide range of potentially damaging agents of microbial, endogenous, and dietary origin that occur within the colonic lumen.
Jeffrey P. Pearson, Iain A. Brownlee
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Colectomia laparoscópica: revisão retrospectiva de 120 casos

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Relatar nossa experiência em cirurgia laparoscópica de cólon e analisar os resultados comparando-os à literatura. MÉTODOS: Analisamos retrospectivamente entre novembro de 1995 e outubro de 2006, 120 pacientes submetidos à ressecções ...
Júlio Cezar Uili Coelho, Renato Valmassoni Pinho, Júlio Japiassú Marinho de Macedo, Paulo César Andriguetto, Antônio Carlos Ligocki Campos   +4 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Protective and therapeutic potentials of Trichinella spiralis larval antigen in murine induced colitis

Scientific Reports
The intolerable side effects and clinical limitations of current conventional therapies for inflammatory bowel diseases (IBDs), there is a pressing need for alternative treatment options.
Enas A. M. Huseein, Samia S. Alkhalil, Hanan S. M. Farghaly, Haiam M. M. Farrag, Hanaa Y. Bakir, Noha M. Aboulhagag, Samah S. M. Mohamed, Mona Gaber   +7 more
doaj   +1 more source

Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer

Gut Pathogens, 2017
Background Recent studies show that some Escherichia coli strains possessing a gene cluster named the pks island might have a causative role in the development of human colorectal cancer (CRC).
Takayuki Shimpoh, Yoshihiro Hirata, Sozaburo Ihara, Nobumi Suzuki, Hiroto Kinoshita, Yoku Hayakawa, Yumiko Ota, Akiko Narita, Shuntaro Yoshida, Atsuo Yamada, Kazuhiko Koike   +10 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

An Ano-recto-sigmoidoscopic Study in Colonic Diseases

Eurasian Journal of Medicine, 2019
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Ahmet Yıldız, Faruk Memik
doaj  

Clinical analysis and identification of pediatric patients with colonic ulceration

BMC Pediatrics
Background A wide variety of diseases mimic inflammatory bowel disease (IBD). This study aimed to reduce the misdiagnosis among children with colonic ulcers.
Yaying You, Yijing Tao, Yanwen Xu, Yi Cao, Haixia Feng, Qingqing Wu, Ying Wang, Weihui Yan   +7 more
doaj   +1 more source

Microbial pathways in colonic sulfur metabolism and links with health and disease

Frontiers in Physiology, 2012
Sulfur is both crucial to life and a potential threat to health. While colonic sulfur metabolism mediated by eukaryotic cells is relatively well studied, much less is known about sulfur metabolism within gastrointestinal microbes.
Franck eCarbonero, Ann C. Benefiel, Amir H. Alizadeh-Ghamsari, H. Rex eGaskins, H. Rex eGaskins, H. Rex eGaskins, H. Rex eGaskins, H. Rex eGaskins   +7 more
doaj   +1 more source