Results 61 to 70 of about 247,377 (298)

A prospective evaluation of the predictive value of faecal calprotectin in quiescent Crohn’s disease [PDF]

, 2014
Background: The faecal calprotectin (FC) test is a non-invasive marker for gastrointestinal inflammation. Aim: To determine whether higher FC levels in individuals with quiescent Crohn’s disease are associated with clinical relapse over the ensuing 12 ...
Allan J. Morris, Beltrán, Best, Boschetti, Centre for Evidence-based purchasing, Cosnes, Costa, D'Haens, D'Incà, Daniel R. Gaya, De Suray, Ferreiro, García-Sánchez, Gisbert, Gisbert, Graham D. Naismith, Guidi, Hanaway, Jack W. Winter, Joanna I. Munro, Jones, Kallel, Karen Rankin, Kennedy, Laharie, Lamb, Langhorst, Lemann, Louis, Lyn A. Smith, Manz, Mao, Molander, Naismith, Pardi, Primas, Roseth, Roseth, Roseth, Sarah J.E. Barry, Saverymuttu, Schoepfer, Schoepfer, Sipponen, Sipponen, Susan Laird, Sutherland, Tibble, Tibble, Van Rheenen, Wagner   +50 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Immunological and genetic features of pathogenetic association between psoriasis and colonic dysbiosis

Инфекция и иммунитет, 2021
Psoriasis is a multifactorial systemic immune-associated disease. It is assumed that colonic dysbiosis may contribute to its development. In this review we provide the data on colonic dysbiosis in induction and progression of psoriatic inflammation ...
A. A. Goncharov, O. V. Dolgikh
doaj   +1 more source

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

¿Se debe seguir usando la preparación preoperatoria de colon? Should preoperative bowel preparation be continued?

Revista Colombiana de Cirugía, 2006
Introducción: La preparación preoperatoria de colon es una conducta practicada frecuentemente por los cirujanos; sin embargo, evidencia reciente pone en duda su efectividad.
Álvaro Sanabria, Eduardo Valdivieso, Gabriel Gómez   +2 more
doaj  

Minilaparotomias para tratamento de doenças do cólon

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Estudar as possibilidades técnicas e resultados obtidos com pequenas incisões para tratar doenças do cólon. MÉTODO: Vinte e seis pacientes, 12 do sexo masculino e 14 do feminino foram submetidos a laparotomias com incisões menores que 10cm.
Peretz Capelhuchnik, Paulo de Azeredo Passos Candelária, Chia Bin Fang, Wilmar Artur Klug, Jorge Alberto Ortiz   +4 more
doaj   +1 more source

Interactions between dietary chicory, gut microbiota and immune responses [PDF]

, 2013
This thesis provides a better understanding of interactions between diet, gut microbiota, and immune responses to a specific dietary fiber source, chicory (Cichorium intybus L).
Liu, Haoyu
core