Guidelines for inflammation models in mice for food components
eFood, 2022 Inflammation is one of the major health threats to humans, and it is associated with various chronic diseases, including metabolic syndrome, type 2 diabetes, cardiovascular diseases, and several types of cancer.
Yanhui Han +3 more
doaj +1 more source
Rapid establishment of human colonic organoid knockout lines
STAR Protocols, 2022 Summary: Human colonic organoids derived from biopsy or autopsy tissues are a vital tool to study mucosal homeostasis, model colonic diseases, and develop therapeutics. Rapid and reliable generation of knockout organoid lines from multiple donors enables
Wei Gu +4 more
doaj +1 more source
Murine fecal microbiota transplantation lowers gastrointestinal pathogen loads and dampens pro-inflammatory immune responses in Campylobacter jejuni infected secondary abiotic mice [PDF]
, 2019 Conventional mice are protected from Campylobacter jejuni infection by the murine host-specific gut microbiota composition. We here addressed whether peroral fecal microbiota transplantation (FMT) might be an antibiotics-independent option to lower even ...
Bereswill, Stefan +2 more
core +1 more source
Establishment of porcine and monkey colonic organoids for drug toxicity study
Cell Regeneration, 2021 Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity, but high cost limits their uses.
Haonan Li +7 more
doaj +1 more source
Acta Medica Iranica, 2023 Changes in the expression of nucleotide-binding oligomerization domain containing 2 (NOD2) play an important role in the pathogenesis of several autoimmune diseases, such as inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ...
Golshid Sanati +6 more
doaj +1 more source
Maternal antibiotic-induced early changes in microbial colonization selectively modulate colonic permeability and inducible heat shock proteins, and digesta concentrations of alkaline phosphatase and TLR-stimulants in swine offspring. [PDF]
PLoS ONE, 2015 Elevated intake of high energy diets is a risk factor for the development of metabolic diseases and obesity. High fat diets cause alterations in colonic microbiota composition and increase gut permeability to bacterial lipopolysaccharide, and subsequent ...
Marie-Edith Arnal +4 more
doaj +1 more source
Deficiency of dietary fiber in Slc5a8-null mice promotes bacterial dysbiosis and alters colonic epithelial transcriptome towards proinflammatory milieu [PDF]
, 2019 Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the intestinal tract due to disruption of the symbiotic relationship between the host immune system and microbiota.
Elmassry, Moamen +6 more
core +2 more sources
Endoscopic Management of Benign Colonic Obstruction and Pseudo-Obstruction [PDF]
Clinical Endoscopy, 2020 There are a variety of causes of intestinal obstruction, with the most common cause being malignant diseases; however, volvulus, inflammatory bowel disease or diverticulitis, radiation injury, ischemia, and pseudo-obstruction can also cause colonic ...
Su Jin Jeong, Jongha Park
doaj +1 more source
Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study [PDF]
, 2016 The short-chain fatty acids (SCFAs), acetate, propionate and butyrate, are bacterial metabolites that mediate the interaction between the diet, the microbiota and the host.
Annaert, Pieter +12 more
core +1 more source
Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions. [PDF]
, 2019 On December 17, 2018, the North American branch of the International Life Sciences Institute (ILSI North America) convened a workshop "Can We Begin to Define a Healthy Gut Microbiome Through Quantifiable Characteristics?" with >40 invited academic ...
Antonopoulos +177 more
core +2 more sources