Results 41 to 50 of about 2,355,621 (296)

Location of human colonic specimens and diseases underlying the surgery.

, 2023
Location of human colonic specimens and diseases underlying the surgery.
Michael Schemann (154153), Klaus Michel (478992), Ihsan Ekin Demir (9364346), Florian Zeller (4952299), Stefanie Schäuffele (15285968), Susanne Hoppe (5849753), Gemma Mazzuoli-Weber (11320525), Kristin Elfers (2633698)   +7 more
core   +1 more source

Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation [PDF]

, 2012
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity.
Allsopp Philip, Magee Pamela, González-Barrio, Rocio, Rocio González-Barrio (117854), McDougall, Gordon J., Gill, Chris I. R., Philip Allsopp (117857), Ian Rowland (117868), Gordon J. McDougall (117848), Gema Pereira-Caro (117851), Derek Stewart, Gema Pereira-Caro, McDougall Gordon J., Crozier Alan, Magee, Pamela, McDougall, G.J., Pamela Magee (117861), Philip Allsopp, Pamela Magee, Stewart Derek, Gordon J McDougall, Pereira-Caro, Gema, Gill Chris I. R., Stewart, D., Ian Rowland, Brown, E.M., Alan Crozier (117865), Brown Emma M., Gill, C.I.R., Pereira-Caro Gema, Derek Stewart (117849), Stewart, Derek, González-Barrio, R., Rowland, Ian, Pereira Caro, G., Emma M. Brown (117847), Rowland Ian, Rocio González-Barrio, Chris I R Gill, Pereira-Caro, G., Alan Crozier, Magee, P., Allsopp, P., González-Barrio, R, Crozier, A., Rowland, I., González-Barrio Rocio, Allsopp, Philip, Emma M Brown, Chris I. R. Gill (117871), Brown, Emma M., Crozier, Alan   +51 more
core   +2 more sources

Maternal antibiotic-induced early changes in microbial colonization selectively modulate colonic permeability and inducible heat shock proteins, and digesta concentrations of alkaline phosphatase and TLR-stimulants in swine offspring. [PDF]

PLoS ONE, 2015
Elevated intake of high energy diets is a risk factor for the development of metabolic diseases and obesity. High fat diets cause alterations in colonic microbiota composition and increase gut permeability to bacterial lipopolysaccharide, and subsequent ...
Marie-Edith Arnal, Jing Zhang, Clett Erridge, Hauke Smidt, Jean-Paul Lallès   +4 more
doaj   +1 more source

Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring

Pharmaceutics, 2021
The increasing prevalence of colonic diseases calls for a better understanding of the various colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools that accurately predict local drug disposition.
Glenn Lemmens, Arno Van Camp, Stephanie Kourula, Tim Vanuytsel, Patrick Augustijns   +4 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Civilization and the colon: Constipation as "the disease of diseases"

Western Journal of Medicine, 2000
The publication in April 2000 of the results of a clinical trial that found high fibre cereals had no protective effect against colorectal adenomas stirred up considerable media attention and shook a cherished tenet of popular health culture.1 After all, boxes of All-Bran have been assuring us for nearly two decades that they contain “at last, some ...
openaire   +5 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Decreased Frequency of Intestinal Regulatory CD5+ B Cells in Colonic Inflammation. [PDF]

PLoS ONE, 2016
BACKGROUND:CD5+ B cells are a type of regulatory immune cells, though the involvement of this B cell subset in intestinal inflammation and immune regulation is not fully understood.
Yoshiyuki Mishima, Shunji Ishihara, Akihiko Oka, Nobuhiko Fukuba, Naoki Oshima, Hiroki Sonoyama, Noritsugu Yamashita, Yasumasa Tada, Ryusaku Kusunoki, Ichiro Moriyama, Takafumi Yuki, Kousaku Kawashima, Yoshikazu Kinoshita   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source