Results 31 to 40 of about 180,158 (258)
Civilization and the colon: Constipation as "the disease of diseases"
Western Journal of Medicine, 2000 The publication in April 2000 of the results of a clinical trial that found high fibre cereals had no protective effect against colorectal adenomas stirred up considerable media attention and shook a cherished tenet of popular health culture.1 After all, boxes of All-Bran have been assuring us for nearly two decades that they contain “at last, some ...
openaire +5 more sources
Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring
Pharmaceutics, 2021 The increasing prevalence of colonic diseases calls for a better understanding of the various colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools that accurately predict local drug disposition.
Glenn Lemmens +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Decreased Frequency of Intestinal Regulatory CD5+ B Cells in Colonic Inflammation. [PDF]
PLoS ONE, 2016 BACKGROUND:CD5+ B cells are a type of regulatory immune cells, though the involvement of this B cell subset in intestinal inflammation and immune regulation is not fully understood.
Yoshiyuki Mishima +12 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Progress in the treatment of colonic diverticular diseases [PDF]
Waike lilun yu shijianThe incidence of colonic diverticular disease is increasing significantly and is showing a trend of youthfulness. The treatment of colonic diverticulum disease mainly involves drugs, including antibiotics, rifaximin, and mesalazine.
KONG Lei, YANG Huali
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Revista Colombiana de Cirugía, 2006 Introducción: La preparación preoperatoria de colon es una conducta practicada frecuentemente por los cirujanos; sin embargo, evidencia reciente pone en duda su efectividad.
Álvaro Sanabria +2 more
doaj