Results 101 to 110 of about 59,560 (374)

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

open access: yesMolecular Oncology, EarlyView.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang   +6 more
wiley   +1 more source

Underwater endoscopic mucosal resection for colorectal lesions: Can it be an “Underwater” revolution?

open access: yesDEN Open, 2022
Underwater endoscopic mucosal resection (UEMR) is a newly developed technique for the removal of colorectal, duodenal, esophageal, gastric, ampullary, and small intestinal lesions.
Yoji Takeuchi   +3 more
doaj   +1 more source

Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer [PDF]

open access: yes, 2013
Author version made available in accordance with Publisher copyright policy.Scope: Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food
Conlon, Michael A   +5 more
core   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

open access: yesMolecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang   +8 more
wiley   +1 more source

Case Report: Collision Tumour of Colon Leiomyosarcoma and Adenocarcinoma [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2016
The colon is an exceedingly rare site of primary leiomyosarcoma and only a few cases have been published to date. Of the reported cases of collision tumours, collision tumours that specifically occurred in the colon have consisted of combinations of ...
Victoria M. Kim   +2 more
doaj   +1 more source

Immunohistochemical testing for Helicobacter Pyloriexistence in neoplasms of the colon [PDF]

open access: yesBMC Gastroenterology, 2008
Helicobacter pylori is a common pathogen, and its prevalence varies with socioeconomic conditions (10-80%). It has recently been recognized as a class I carcinogen in relation to gastric cancer. The aim of this study was to investigate the presence of Helicobacter pylori in neoplasms of the colon by immunohistochemical methods.The polypectomy materials
Halil Alis   +6 more
openaire   +4 more sources

Estimating the coverage in 3d reconstructions of the colon from colonoscopy videos [PDF]

open access: yesarXiv, 2022
Colonoscopy is the most common procedure for early detection and removal of polyps, a critical component of colorectal cancer prevention. Insufficient visual coverage of the colon surface during the procedure often results in missed polyps. To mitigate this issue, reconstructing the 3D surfaces of the colon in order to visualize the missing regions has
arxiv  

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

open access: yesMolecular Oncology, EarlyView.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Use of colonoscopy as a primary screening test for colorectal cancer in average risk people [PDF]

open access: yes, 2003
The use of colonoscopy as a primary screening test for colorectal cancer (CRC) in average risk adults is a subject of controversy. Our primary objective was to build a predictive model based on a few simple variables that could be ...
Angós, R. (Ramón)   +9 more
core  

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