Results 111 to 120 of about 188,867 (352)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Prognostic value of FBXW7 tumor suppressor gene expression and mutations in patients with colorectal cancer: A meta-analysis

Cancer Treatment and Research Communications
Background: Colorectal cancer (CRC) ranks as the second most common cause of cancer-related mortality globally. The tumor suppressor gene FBXW7 is considered to play a key role in determining patient prognosis.
Mohammad Rahmanian, Iman Elahi Vahed, Mohammad Shirali, Raheleh Charmchi, Amirreza Noura, Narges Khaleghi gazik, Reza Senobari, Zahra Rasouli, Mohammadsadegh Jafari, Shokoofeh Noori   +9 more
doaj   +1 more source

Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms [PDF]

, 2014
Michael Selgrad, Jan Bornschein, Arne Kandulski, Carla Hille, Jochen Weigt, Albert Roessner, Thomas Wex, Peter Malfertheiner   +7 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cellular Expression Patterns of Genes Upregulated in Murine and Human Colonic Neoplasms [PDF]

, 2008
Xiaodi Chen, W. Ehrhardt, Richard B. Halberg, Bruce J. Aronow, William F. Dove   +4 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Metastatic Colonic Adenocarcinoma in Breast: Report of Two Cases and Review of the Literature

Case Reports in Oncological Medicine, 2015
Metastatic adenocarcinoma to the breast from an extramammary site is extremely rare. In the literature, the most current estimate is that extramammary metastases account for only 0.43% of all breast malignancies and that, of these extramammary sites ...
Jiten P. Kothadia, Rezina Arju, Monica Kaminski, Arvind Ankireddypalli, Sushil Duddempudi, Jonathan Chow, Shah Giashuddin   +6 more
doaj   +1 more source

Successful Simultaneous Treatment of Benign Stricture and Colonic Neoplasm Arising from Colonic Interposition after Esophagectomy: A Case Report

, 2023
Seung Hee Kim, Jin Won Kim, Seon‐Young Park, Hyun‐Soo Kim, Chae June Lim, Gang Han Lee, Jae Woong Lim, Young Eun Seo, Chul‐Kee Park, Yo Han Lee, Yong Wook Jung, Woo Rim Kang, Hye-Su You, Dong Hyun Kim   +13 more
openalex   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source