Results 111 to 120 of about 796,081 (400)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

The angular spectrum of the scattering coefficient map reveals subsurface colorectal cancer [PDF]

, 2019
Colorectal cancer diagnosis currently relies on histological detection of endoluminal neoplasia in biopsy specimens. However, clinical visual endoscopy provides no quantitative subsurface cancer information.
Chapman, William C., Jr., Chatterjee, Deyali, González, Iván, Mutch, Matthew, Nandy, Sreyankar, Rais, Rehan, Rao, Bin, Zeng, Yifeng, Zhu, Quing   +8 more
core   +3 more sources

Estimating the coverage in 3d reconstructions of the colon from colonoscopy videos [PDF]

arXiv, 2022
Colonoscopy is the most common procedure for early detection and removal of polyps, a critical component of colorectal cancer prevention. Insufficient visual coverage of the colon surface during the procedure often results in missed polyps. To mitigate this issue, reconstructing the 3D surfaces of the colon in order to visualize the missing regions has
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Endoscopy : an evolving speciality [PDF]

, 2005
The practice of endoscopy has been rapidly changing due to new emerging technologies and novel techniques. There has been more focus on colonoscopy training with the development of structured programmes including simulators.
Arebi, Naila, Saunders, Brian P., Surgical Procedures, Endoscopic   +2 more
core  

The impact of colonoscopy on the early detection of colonic neoplasms in patients with rectal bleeding.

Annals of Surgery, 1987
A retrospective analysis was made of 372 consecutive patients who underwent colonoscopy because of rectal bleeding. The three distinct patterns of bleeding studied were chronic (224 cases), recent major (93 cases), and acute bleeders (55 cases).
J. Guillem, K. Forde, M. Treat, A. I. Neugut, Carol A. Bodian   +4 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

, 2013
We present an ex vivo study of temporally and spectrally resolved autofluorescence in a total of 47 endoscopic excision biopsy/resection specimens from colon, using pulsed excitation laser sources operating at wavelengths of 375 nm and 435 nm.
Chorvat, Chwirot, Chwirot, Cothren, Cothren, Cross, Curvers, De Beule, Drezek, Duraipandian, Eker, Fang, Georgakoudi, Georgakoudi, Glanzmann, Gono, Hilska, Hotouras, Huang, Jo, Kapadia, Kara, Kiesslich, Lambert, Li, Lin, Lovat, Maarek, Manning, Marcu, Mayinger, Mayinger, Mayinger, McGinty, Mizeret, Mycek, Nakaniwa, Nakashima, Palero, Palmer, Pfefer, Pitts, Ramanujam, Rex, Richards-Kortum, Schomacker, Schomacker, Schweitzer, Shao, Shim, Skala, Taplin, Thompson, Vishwasrao, Vogelstein, Wagnières, Wallace, Wang, Williams, Xiao, Yang, Zhuo, Zhuo, Zhuo, Zhuo, Zonios   +65 more
core   +1 more source

The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients.

Journal of Clinical Endocrinology and Metabolism, 2007
CONTEXT Hyperinsulinemia is associated with colon carcinoma in the general population. PATIENTS with acromegaly are considered to be at risk for developing colonic lesions and typically have hyperinsulinemia. OBJECTIVE Our objective was to evaluate the
A. Colao, R. Pivonello, R. Auriemma, M. Galdiero, D. Ferone, F. Minuto, P. Marzullo, G. Lombardi   +7 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source