Results 261 to 270 of about 185,360 (305)

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

open access: yesAdvanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie   +10 more
wiley   +1 more source

Partial resections of the liver [PDF]

open access: yes, 1977
Putnam, CW, Starzl, TE
core  

Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion

open access: yesAdvanced Science, EarlyView.
Steroid receptor coactivator‐1 (SRC‐1) reprograms tumor‐associated macrophages (TAMs) via signal transducer and activator of transcription 1(STAT1)‐mediated matrix metallopeptidase 12 (MMP12) transcription to drive perineural invasion (PNI) in pancreatic cancer.
Ke Cheng   +9 more
wiley   +1 more source

A Case of APC Gene Mutation-Associated Familial Adenomatous Polyposis With Multiple System Malignancies. [PDF]

open access: yesCancer Rep (Hoboken)
Yijing R   +6 more
europepmc   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

open access: yesAdvanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao   +9 more
wiley   +1 more source

Schwannoma of the colon presenting as a submucosal lesion: diagnostic challenge and surgical management. [PDF]

open access: yesJ Surg Case Rep
Al Yaseen M   +5 more
europepmc   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao   +10 more
wiley   +1 more source

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