Results 81 to 90 of about 796,081 (400)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Endoscopic submucosal dissection in the West
International Journal of Gastrointestinal Intervention, 2019 Endoscopic resection has emerged as the first line therapy for pre-malignant conditions throughout the gastrointestinal (GI) tract. Resection techniques have evolved from forceps avulsion and snare polypectomy to endoscopic mucosal resection (EMR) and ...
Alexander Podboy, Shai Friedland
doaj +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Hierarchical Phenotyping and Graph Modeling of Spatial Architecture in Lymphoid Neoplasms [PDF]
arXiv, 2021 The cells and their spatial patterns in the tumor microenvironment (TME) play a key role in tumor evolution, and yet the latter remains an understudied topic in computational pathology. This study, to the best of our knowledge, is among the first to hybridize local and global graph methods to profile orchestration and interaction of cellular components.
arxiv
Mucosubstances in neoplasms of the human colon and rectum [PDF]
Gut, 1971 The patterns of mucosubstances secreted in the normal human colon and rectum, in benign tumours, and in and around malignant tumours of the colon and rectum have been studied. Very little neutral mucosubstance was seen in normal specimens; the secretion in these was made up of sulphated and nonsulphated acid mucosubstances, with the former ...
openaire +3 more sources
Tumor heterogeneity in neoplasms of breast, colon, and skin [PDF]
BMC Research Notes, 2010 Different cell subpopulations in a single tumor may show diverse capacities for growth, differentiation, metastasis formation, and sensitivity to treatments. Thus, heterogeneity is an important feature of tumors. However, due to limitations in experimental and analytical techniques, tumor heterogeneity has rarely been studied in detail.Different tumor ...
Li, Jian +5 more
openaire +5 more sources
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
On the proper treatment of pathologies in biomedical ontologies [PDF]
, 2005 In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a and part_of can support new types of auto-mated reasoning about biomedical phenomena.
Kumar, Anand, Smith, Barry
core
Preoperative localization of potentially invisible colonic lesions on the laparoscopic operation field: using autologous blood tattooing [PDF]
Annals of ColoproctologyPurpose Preoperative colonoscopic (POC) localization is recommended for patients scheduled for elective laparoscopic colectomy for early colon cancer. Among the various localization method, POC tattooing localization has been widely used.
Ji Yeon Mun +4 more
doaj +1 more source