Results 231 to 240 of about 193,424 (324)

Tumor‐Tissue Boundaries as Instructive Interfaces in Breast Cancer Cell Invasion

Advanced Science, EarlyView.
Tumor‐tissue boundaries reprogram metastatic breast cancer cells, enhancing invasiveness through an instructive, not permissive, mechanism. Using a 3D collagen I‐based tumor‐tissue interface model, single‐cell analysis, and simulations, this study shows that all cells can transmigrate without selective filtering, highlighting a targetable process in ...
Cornelia Clemens, Thomas Zerjatke, Andrine Frank, Hannah Trampert, Nataliia Kotsiuba, Ingmar Glauche, Tilo Pompe   +6 more
wiley   +1 more source

Candidal speciation and carriage in oral cavity of HIV-positive children/adults and healthy individuals in the South Canara district of India: a comparative study. [PDF]

BMC Res Notes
Ks S, Natarajan S, Boaz K, Baliga S, Ramapuram J, Solomon MC, Manaktala N, Chitra NS.   +7 more
europepmc   +1 more source

Intravenous iRGD‐Guided, RBC‐Membrane Camouflaged Lactococcus Lactis Remodels Cold NSCLC and Enhances PD‐1 Blockade

Advanced Science, EarlyView.
This study presents an engineered probiotic platform, iRGD‐mRBC@FOLactis, combining red blood cell membrane cloaking and tumor‐penetrating peptide iRGD for enhanced PD‐1 blockade. The platform improves tumor targeting, immune cell activation and therapeutic efficacy in lung cancer, demonstrating significant promise in overcoming PD‐1/PD‐L1 therapy ...
Chen Chen, Junmeng Zhu, Xiao Liu, Jie Shao, Aoxing Chen, Yi Mei, Xinyin Zhang, Qinyi Chen, Lin Li, Baorui Liu   +9 more
wiley   +1 more source

Magnitude of vancomycin-resistant <i>Enterococci</i> colonization and associated factors among people living with HIV. [PDF]

JAC Antimicrob Resist
Dawud A, Shume T, Sarkar R, Maru M, Wakjira OG, Prajapati AK, Marami D, Tesfa T.   +7 more
europepmc   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source

Assessment of the potential of novel Californian grapevine <i>Trichoderma</i> isolates to reduce colonization of fungal trunk canker pathogens and <i>Xylella fastidiosa</i>. [PDF]

Front Plant Sci
Wallis CM, Shinde R, Ellis ML, Gorman Z, Mekdara N.   +4 more
europepmc   +1 more source

The Colonial Origins of Comparative Development: An Empirical Investigation

, 2000
D. Acemoglu, Simon Johnson, James A. Robinson   +2 more
semanticscholar   +1 more source

Hypoxia‐Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis

Advanced Science, EarlyView.
Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou, Shuying Qiu, Xia Yang, Yan Wu, Xinxia Yao, Hangqi Hu, Jingfeng Luo, Chandra Sugiarto Wijaya, Lingfeng Ma, Xiaojun Long, Lingna Xu, Jinquan Liu, Chaoqun Wang, Yibin Pan, Xiaona Chen, Hongchuan Jin, Xian Wang   +16 more
wiley   +1 more source

Growth and skeletal structure of the parasitic zoantharian Savalia savaglia (Bertoloni, 1819). [PDF]

Sci Rep
Canessa M, Bo M, Boggia R, Calcagnile L, D'Elia M, Orlandi V, Quarta G, Trainito E, Turrini F, Bavestrello G.   +9 more
europepmc   +1 more source

Review of Meuwese\u27s Brothers in Arms, Partners in Trade: Dutch-Indigenous Alliances in the Atlantic World, 1595-1674

, 2013
Otto, Paul
core