Results 31 to 40 of about 112,149 (247)

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

The role of colonoscopy in the management of intestinal obstruction: a 20-year retrospective study

BMC Gastroenterology, 2010
Purpose The aim of the study was to assess the use colonoscopy over time in the assessment of large bowel obstruction in a tertiary university hospital.
Christodoulou Dimitrios K, Ignatiadou Eleftheria, Tatsioni Athina, Maliouki Mariana, Katsanos Konstantinos H, Fatouros Michael, Tsianos Epameinondas V   +6 more
doaj   +1 more source

Bowel Cleansing Protocol in Colonoscopy: Does It Affect Blood Thiamine Level?

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Background: The burden of vitamin B1 or thiamine deficiency in patients undergoing digestive surgery is quite enormous. In the field of gastroenterology, pre-colonoscopy preparation might affect thiamine level.
Rabbinu Rangga Pribadi, Virly Nanda Muzellina, Marcellus Simadibrata   +2 more
doaj   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

The Cost-Effectiveness of AI-Assisted Colonoscopy as a Primary or Secondary Screening Test in a Population-Based Colorectal Cancer Screening Program: Markov Modeling–Based Cost Effectiveness Analysis

Journal of Medical Internet Research
BackgroundColorectal cancer (CRC) is the third most common cancer worldwide and poses a heavy burden on health care systems.
Martin CS Wong, Junjie Huang, Thomas YT Lam, Louis HS Lau, Philip WY Chiu   +4 more
doaj   +1 more source

Patients without colonoscopic follow-up after abnormal fecal immunochemical tests are often unaware of the abnormal result and report several barriers to colonoscopy

BMC Gastroenterology, 2020
Background The fecal immunochemical test (FIT) is the second most commonly used colorectal cancer (CRC) screening modality in the United States; yet, follow-up of abnormal FIT results with diagnostic colonoscopy is underutilized.
Vivy T. Cusumano, Edgar Corona, Diana Partida, Liu Yang, Christine Yu, Folasade P. May   +5 more
doaj   +1 more source

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

Advanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning, Munir H. Buhaya, Victor V. Nguyen, Afeefah Khazi‐Syed, Haider A. Ali, Adil Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, Victor D. Varner, Cheryl M. Lewis, Emina H. Huang, Jacopo Ferruzzi   +18 more
wiley   +1 more source

Quality indicators of colonoscopy care: a qualitative study from the perspectives of colonoscopy participants and nurses

BMC Health Services Research, 2022
Background Quality of care in colonoscopy is closely related to colonoscopy participants and the nursing workforce in endoscopy-related settings. However, limited data are available on the evaluations and recommendations regarding quality indicators for ...
Wenwen Cai, Xingxing Zhang, Yanxia Luo, Minshan Ye, Yu Guo, Weiqing Ruan   +5 more
doaj   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Adverse events associated with colonoscopy; an examination of online concerns

BMC Gastroenterology, 2019
Background Colonoscopy as a screening and diagnostic tool is generally safe and well-tolerated, and significant complications are rare. The rate of more mild adverse effects is difficult to estimate, particularly when such effects do not result in ...
Elad Yom-Tov, Benjamin Lebwohl
doaj   +1 more source