Results 51 to 60 of about 1,118,799 (244)

Continuous function optimization using hybrid ant colony approach with orthogonal design scheme [PDF]

, 2006
A hybrid Orthogonal Scheme Ant Colony Optimization (OSACO) algorithm for continuous function optimization (CFO) is presented in this paper. The methodology integrates the advantages of Ant Colony Optimization (ACO) and Orthogonal Design Scheme (ODS ...
Jun Zhang, Jing-hui Zhong, Zhong, J., Wei-neng Chen, Yun Li, Li, Y., Chen, W., Zhang, J., Tan, X., Xuan Tan   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Safe and cost-effective treatment response monitoring of MDR pulmonary tuberculosis by using micro colony broth culture method

International Journal of Mycobacteriology, 2015
Aims and objectives: Multidrug resistant tuberculosis (MDR-TB) management is expensive, prolonged and complicated. After starting anti-tuberculous treatment in MDR-TB patients, microbiological response to therapy is monitored by monthly sputum cultures ...
S Irfan, K Jabeen, M Irfan, N A Rao, Z Azizullah, R Hasan   +5 more
doaj  

Use of Hive Debris to Detect Acute Bee Paralysis Virus, Chronic Bee Paralysis Virus and Deformed Wing Virus in Honey Bees: An Innovative and Non‐Invasive Approach

Veterinary Medicine and Science
Honey bees are affected by several pathogens, including different RNA viruses such as Acute Bee Paralysis Virus (ABPV), Chronic Bee Paralysis Virus (CBPV) and Deformed Wing Virus (DWV). Real‐time PCR (RT‐PCR) is a standard method to detect these viruses,
Silvia Olivieri, Luca Carisio, Paola Mogliotti, Cecilia Guasco, Alberico Franzin, Annalisa Garrone, Fulvio Brusa   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Organization of honeydew collection by foragers of different species of ants (Hymenoptera: Formicidae): Effect of colony size and species specificity

European Journal of Entomology, 2015
Aphid honeydew is one of the main energy sources for various ants in the temperate zone, nevertheless relatively little is known about the organization of the work of honeydew foragers (aphid milkers).
Tatiana A. NOVGORODOVA
doaj   +1 more source

Critical steps to tumor metastasis: alterations of tumor microenvironment and extracellular matrix in the formation of pre-metastatic and metastatic niche

Cell & Bioscience, 2020
For decades, cancer metastasis has been a heated topic for its high mortality. Previous research has shown that pre-metastatic niche and metastatic niche are the 2 crucial steps in cancer metastasis, assisting cancerous cells’ infiltration, survival, and
Jianan Zhuyan, Mingyu Chen, Tianhao Zhu, Xunxia Bao, Timing Zhen, Kaichen Xing, Qiubo Wang, Sibo Zhu   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source