Results 41 to 50 of about 386,188 (263)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Which Three-Dimensional Printing Technology Can Replace Conventional Manual Method of Manufacturing Oral Appliance? A Preliminary Comparative Study of Physical and Mechanical Properties

Applied Sciences, 2021
Three-dimensional printing technology is widely being adopted in the manufacturing of oral appliances. The purpose of this study was to determine the most suitable method of manufacturing oral appliances by comparing the physical and mechanical ...
Hyo-Jin Kim, Seung-Weon Lim, Mi-Kyung Lee, Sung Won Ju, Suk-Hee Park, Jin-Soo Ahn, Kyung-Gyun Hwang   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Evaluation of the Color Stability, Stainability, and Surface Roughness of Permanent Composite-Based Milled and 3D Printed CAD/CAM Restorative Materials after Thermocycling

Applied Sciences, 2023
With the developments in digital dentistry in recent years, subtractive and additive manufacturing and materials have emerged for the production of dental restoration.
Hatice Nalan Bozoğulları, Tuğba Temizci   +1 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Effect of staining beverages on color stability of composite: A spectrophotometric study

Journal of Pharmacy and Bioallied Sciences
Objective: This study used spectrophotometry to examine how staining beverages affect the color stability of three commercial composite materials (nanohybrid composite (A), bulk fill composite (B), and flowable composite (C)) over time.
Radhika Thakkar, Anuj P Maini, Sahil Mogla, Syed Shah Hussain Qadri, Praveen K Varma, Alok Dubey   +5 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Influence of Food Pigments and Thermal Aging on the Color Stability of Denture Base Resins

Applied Sciences
Color stability of acrylic resins is essential for preserving the aesthetic appearance of denture bases over time. This study explores how food pigments and thermal changes affect the color stability of commonly used denture base resins.
Beatriz Costa, Cristina Bettencourt Neves, João Carlos Roque, Vitor Anes, Virgínia Santos   +4 more
doaj   +1 more source

Evaluation of the Effect of Different Herbal Tea on Discoloration of Different Kinds of Composite [PDF]

Journal of Dental Materials and Techniques, 2016
Objectives: The aim of this study was to evaluate the effect of six herbal teas on the color stability of two types of nanohybrid and one microhybrid resin composite.  Materials and Methods: 70 disc-shaped specimens, 210 in total (7*2mm), were fabricated
Fatemeh Nezhadnasrollah, Farzin Shahrokhzadeh, Hemmat Gholinia   +2 more
doaj   +1 more source