Results 151 to 160 of about 31,445 (293)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Combined Transcriptomic and Metabolomic Analysis of the Coloration Mechanism in Colored-Leaf <i>Osmanthus fragrans</i> 'Jinyu Guihua'. [PDF]

Plants (Basel)
Guo P, Huang Y, Jin P, Li X, Ma Q, Yu L, Zhao W, Wang Y, Shang F.   +8 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Integrative analysis of the transcriptome and metabolome reveals the peel coloration mechanism of Zanthoxylum armatum. [PDF]

BMC Plant Biol
Ren Y, Liu J, He L, Jiang J, Gong T, Zhou Q, Li Q, Liu J, Tang N, Chen Z.   +9 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

In-Depth Exploration of the Coloration Mechanism of <i>Iris dichotoma</i> Pall. via Transcriptomic and Metabolomic Analyses. [PDF]

Plants (Basel)
Yu Y, Qiang X, Huang F, Huang X, Liu L.
europepmc   +1 more source

Cosmetic enhancement of signal coloration: experimental evidence in the house finch

Plumage coloration plays an important role in visual communication by signaling aspects of individual quality. It has been proposed that the need for preserving plumage condition and hence signaling content may have promoted a novel signaling mechanism ...
Iluminada Pagán, Isabel López-Rull, Constantino Macías Garcia   +2 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Metabolome and transcriptome integration reveals insights into petals coloration mechanism of three species in Sect. Chrysantha chang. [PDF]

PeerJ
Yan Y, Wang Y, Wen Y, Huang Y, Zhang M, Huang J, Li X, Wang C, Xu D.   +8 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source