Results 81 to 90 of about 2,925,624 (251)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Independent Consultation and Investigation Mechanism: Annual Report 2014 [PDF]

, 2015
One of the most important milestones of 2014 was the approval of the new MICI Policy by the Bank\u27s Board of Executive Directors on December 17, 2014 after 18 months of extensive revision, which entered into force immediately after its approval.
Inter-American Development Bank
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Female mating preferences and male coloration covary with water transparency in a Lake Victoria cichlid fish [PDF]

, 2010
Rapid speciation in Lake Victoria cichlid fish of the genus Pundamilia may be facilitated by sexual selection: female mate choice exerts sexual selection on male nuptial coloration within species and maintains reproductive isolation between species ...
Seehausen, Ole, Van Alphen, J.J.M., Maan, Martine E.   +2 more
core   +1 more source

Comparative transcriptome analysis of Lupinus polyphyllus Lindl. provides a rich molecular resource for research on coloration mechanism. [PDF]

PeerJ, 2022
Gao Z, Mao J, Chen L, Wang X, Zhang L.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Seasonal change in defensive coloration in a shieldbug [Elektronisk resurs]

, 2011
Protective coloration such as aposematism and crypsis occurs in many insects but only a few species alter their defensive strategy during the same instar. We hypothesize the adult shield bug Graphosoma lineatum with an alternating black and non-melanised
Johansen, Aleksandra Irene,
core  

Shroud like coloration of linen, conservation measures and perception of patterns onto the Shroud of Turin

SHS Web of Conferences, 2015
We present new experimental results on ultraviolet laser processing of linen fabrics that complete and update the previous studies at the ENEA Research Centre of Frascati seeking a coloration mechanism able to reproduce the microscopic complexity of the ...
Lazzaro Paolo Di, Murra Daniele
doaj   +1 more source

Spectrometric Determination of Copper With Carbon Nanotubes

International Journal of Electrochemical Science, 2011
In this work, a novel and sensitive spectrometric method for determination of copper was developed with carbon nanotubes (CNTs) as a toner. The optimum operating conditions regarding kind of CNTs, concentration of reagents and pH were established.
Qiang Yin, Quanshui Chen, Yongyu Liu, Xiong Chen, Tianyu Wei, Ye Li   +5 more
doaj   +1 more source