Results 51 to 60 of about 560,673 (261)

A rare case of Amyand’s hernia presenting as an enterocutaneous fistula

Journal of Surgical Case Reports, 2010
The finding of the vermiform appendix in an inguinal hernia has an incidence of approximately 1%. The condition is given the eponymous name Amyand’s hernia. However in just 0.08% the condition is complicated by an acute appendicitis.
L Flood, KH Chang, OJ McAnena
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Síndrome de Peutz - Jeghers: Seguimiento de una familia Syndrome of Peutz - Jeghers: Follow to family

Revista Colombiana de Cirugía, 2007
El síndrome Peutz - Jeghers es una enfermedad con pólipos del colon con un patrón autosómico dominante, su tipo histológico es hamartomatoso y aunque es muy rara la transformación maligna, se ha postulado una secuencia hamartoma - carcinoma.
María Helena Gaitán Buitrago, Alejandro Vélez Hoyos, Luis G Carvajal-Carmona, José Ignacio Restrepo R, Hernán Restrepo, Mario Hernán Ruiz Vélez, Fabián Juliao Baños, Rodrigo Castaño Llano   +7 more
doaj  

A Novel Experimental Model of Colorectal Endometriosis

Journal of Investigative Surgery, 2018
Purpose: Endometriosis is a disease that affects 6–10% of the female population, mainly women of reproductive age, and causes a variety of cyclic symptoms.
Anastasia Prodromidou, Vasilios Pergialiotis, Kitty Pavlakis, Laskarina Maria Korou, Maximos Frountzas, Dimitrios Dimitroulis, Georgios Vaos, Despina N. Perrea   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Long-Term Outcomes of the Obstruction Treatment in Benign and Malignant Colonic Obstruction: A Multicentre Study

Journal of Coloproctology
Introduction Patients with colonic obstruction are at risk for emergency resection, which is a risk factor for increased mortality and morbidity. In left-sided obstructive colon cancer, the principle of bridge-to-surgery is already recommended
Bo P. Smalbroek, Lea M. Dijksman, Johanne Bloemen, Anke B. Smits   +3 more
doaj   +1 more source

Perianal Abscess

Journal of Education and Teaching in Emergency Medicine, 2018
History of present illness: 31-year-old male with history of human immunodeficiency virus (HIV) presented with complaints of pain and redness to the right inner buttock; vital signs were within normal limits.
Luke Walls-Smith, Jonathan Peña
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers

Diseases, 2018
Wine has been popular worldwide for many centuries and currently remains an important component of our diet. Scientific interest in wine and its health effects has grown considerably since the 1990s with the emergence of the “French Paradox„ ...
Souheila Amor, Pauline Châlons, Virginie Aires, Dominique Delmas   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source