Results 71 to 80 of about 284,773 (249)

A Novel Experimental Model of Colorectal Endometriosis

Journal of Investigative Surgery, 2018
Purpose: Endometriosis is a disease that affects 6–10% of the female population, mainly women of reproductive age, and causes a variety of cyclic symptoms.
Anastasia Prodromidou, Vasilios Pergialiotis, Kitty Pavlakis, Laskarina Maria Korou, Maximos Frountzas, Dimitrios Dimitroulis, Georgios Vaos, Despina N. Perrea   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population [PDF]

, 2006
Background Bowel cancer is common and is a major cause of death. Meta-analysis of randomised controlled trials estimates that screening for colorectal cancer using faecal occult blood (FOB) test reduces mortality from colorectal cancer by 16%.
Redman, VD, Michael JO Wakelam, Colbourne, L, Janet A Dunn, Val D Redman, Lynne Colbourne, Dunn, Janet, Martin, A, Martin Ashley, Wilson, S, Wakelam, Michael, Ismail, T, Hobbs Richard FD, Wakelam, Michael J.O., Sue Wilson, Hobbs, RFD, Martin, Ashley, Wilson, Sue, Dr, Redman, Valerie, Colbourne Lynne, Wakelam, MJ, Redman, Val. D., Colbourne, Lynne, Ryan, Angela V., Wilson Sue, Angela V Ryan, Ryan, AV, Tariq Ismail, Fiona Patrick, Ashley Martin, Richard FD Hobbs, Ryan Angela V, Patrick, Fiona, Patrick, F, Ismail, Tariq, Ismail Tariq, Dunn, Janet A., Wilson, Sue, Redman Val D, Ryan, Angela, Dunn Janet A, Wakelam, MJO, Hobbs, RF, Dunn, JA, Hobbs, Richard F. D., Patrick Fiona, Wakelam Michael JO   +46 more
core   +2 more sources

Long-Term Outcomes of the Obstruction Treatment in Benign and Malignant Colonic Obstruction: A Multicentre Study

Journal of Coloproctology
Introduction Patients with colonic obstruction are at risk for emergency resection, which is a risk factor for increased mortality and morbidity. In left-sided obstructive colon cancer, the principle of bridge-to-surgery is already recommended
Bo P. Smalbroek, Lea M. Dijksman, Johanne Bloemen, Anke B. Smits   +3 more
doaj   +1 more source

Perianal Abscess

Journal of Education and Teaching in Emergency Medicine, 2018
History of present illness: 31-year-old male with history of human immunodeficiency virus (HIV) presented with complaints of pain and redness to the right inner buttock; vital signs were within normal limits.
Luke Walls-Smith, Jonathan Peña
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers

Diseases, 2018
Wine has been popular worldwide for many centuries and currently remains an important component of our diet. Scientific interest in wine and its health effects has grown considerably since the 1990s with the emergence of the “French Paradox„ ...
Souheila Amor, Pauline Châlons, Virginie Aires, Dominique Delmas   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Study protocol for BeWEL: The impact of a BodyWEight and physicaL activity intervention on adults at risk of developing colorectal adenomas [PDF]

, 2011
Background: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second highest cause of cancer death in the UK. Most cases occur in people over 50 years and CRC often co-exists with other lifestyle related disorders including ...
Belch, Jill J F, Steele, RJC, Anderson, Annie, Steele, Robert J C, Jackie Rodger, Angela M Craigie, Treweek, S, Daly, Fergus, Stead, Martine, Annie S Anderson, Steele, R J, Anderson, A S, Kirk, A, Caswell, Stephen, Ludbrook, Anne, Wardle, J., Anne Ludbrook, Caswell, S, Belch, JJF, Ludbrook, A, Jill JF Belch, Craigie, Angela M, Steele, Robert J. C., Fergus Daly, Alison Kirk, Treweek, S., Joyce Thompson, Anderson, Annie S.; id_orcid, Craigie, Angela M.; id_orcid, Belch, Jill J. F.; id_orcid, Shaun Treweek, Craigie, AM, Belch, Jill, Craigie, A, Kirk, Alison, Jane Wardle, Wardle, Jane, Martine Stead, Stephen Caswell, Belch, J, Paterson, C, Anderson, AS, Anderson, Annie S, Treweek, Shaun, Stead, M, Paterson, Caron, Rodger, Jackie, Caron Paterson, Rodger, J, Thompson, J, Robert JC Steele, Steele, Robert, Thompson, Joyce, Craigie, Angela, Wardle, J, Daly, F, Anderson Annie S, Craigie Angela M, Stead Martine, Wardle Jane, Treweek Shaun, Thompson Joyce, Rodger Jackie, Daly Fergus, Steele Robert JC, Paterson Caron, Kirk Alison, Ludbrook Anne, Belch Jill JF, Caswell Stephen   +69 more
core   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source