Results 141 to 150 of about 5,289,946 (346)

The Effects of Family History of Colorectal Cancer on the Development of Colorectal Adenoma [PDF]

, 2012
Min Young Choi, Byeong Gwan Kim, Ji Won Kim, Kook Lae Lee, Ji Bong Jeong, Jaekyung Lee, Yong Jin Jung, Won Kim, Dong‐Won Ahn, Young‐Hoon Kim, Sae Kyung Joo, Mee Soo Chang, Hyeoung Ju Kwon   +12 more
openalex   +1 more source

Supplemental Figures from Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription

, 2023
Bryson W. Katona, Rebecca A. Glynn, Kayla E. Paulosky, Zijie Feng, Caroline I. Davis, Jian Ma, Corbett T. Berry, Katherine M. Szigety, Smita Matkar, Yuanyuan Liu, Haoren Wang, Wu Yuan, Xin He, Bruce D. Freedman, Donita C. Brady, Xianxin Hua   +15 more
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Hereditary non-polyposis colorectal cancer (HNPCC) and its genetic basis

, 2023
zulqarnain bhalwal
openalex   +2 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.

New England Journal of Medicine, 2004
H. Hurwitz, L. Fehrenbacher, W. Novotny, T. Cartwright, J. Hainsworth, W. Heim, J. Berlin, A. Baron, S. Griffing, E. Holmgren, N. Ferrara, G. Fyfe, B. Rogers, R. Ross, F. Kabbinavar   +14 more
semanticscholar   +1 more source

The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways

, 2017
Mаhmoud Youns, Wael A. H. Hegazy
openalex   +2 more sources

Previously unrecognized genetic mutations in colorectal and breast cancers [PDF]

, 2006

openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source