Results 141 to 150 of about 5,474,833 (393)

FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer

Cell Communication and Signaling, 2020
Background Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients.
Weixing Dai, Xianke Meng, Shaobo Mo, Wenqiang Xiang, Ye Xu, Long Zhang, Renjie Wang, Qingguo Li, Guoxiang Cai   +8 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Efficient Colon Cancer Grading with Graph Neural Networks [PDF]

arXiv, 2020
Dealing with the application of grading colorectal cancer images, this work proposes a 3 step pipeline for prediction of cancer levels from a histopathology image. The overall model performs better compared to other state of the art methods on the colorectal cancer grading data set and shows excellent performance for the extended colorectal cancer ...
arxiv  

Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma. [PDF]

, 2018
Adherence to the American Cancer Society's (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines is associated with reductions in overall cancer incidence and mortality, including site-specific cancers such as colorectal cancer.
Harris, Robin B, Jacobs, Elizabeth T, Kohler, Lindsay N, Lance, Peter, Oren, Eyal, Roe, Denise J   +5 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Adjuvant chemotherapy for rectal cancer with complete pathological response (pCR) may not be necessary: a pooled analysis of 5491 patients

Cancer Cell International, 2019
Background It is recommended postoperative adjuvant chemotherapy for all rectal cancers undergoing neo-chemoradiotherapy regardless of the final yield pathology.
Xiang Hu, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai, Jun-Jie Peng   +5 more
doaj   +1 more source

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi‐Society Task Force on Colorectal Cancer, and the American College of Radiology * †

Ca, 2008
In the United States, colorectal cancer (CRC) is the third most common cancer diagnosed among men and women and the second leading cause of death from cancer.
B. Levin, D. Lieberman, B. McFarland, Robert A Smith, D. Brooks, Kimberly S. Andrews, C. Dash, F. Giardiello, S. Glick, T. Levin, Perry Pickhardt, D. Rex, A. Thorson, S. Winawer   +13 more
semanticscholar   +1 more source

Colorectal Cancer Screening Behaviors among American Indians in the Midwest

, 2012
Colorectal cancer is the second most diagnosed cancer among American Indians and is also the second leading cause of cancer death. We used a community-based participatory approach to conduct a mixed methods study to examine colorectal cancer screening ...
Choi, Won S., Daley, Christine M., Greiner, K. A., James, Aimee S., Nazir, Niaman   +4 more
core  

Get screened: a pragmatic randomized controlled trial to increase mammography and colorectal cancer screening in a large, safety net practice [PDF]

, 2010
Background Most randomized controlled trials of interventions designed to promote cancer screening, particularly those targeting poor and minority patients, enroll selected patients.
AB Varkey, AC Feldstein, Amanat Yosha, Amna Adris, AN Trivedi, C Bejes, CN Klabunde, CR Jaen, CR Jaen, DC Dugdale, DL Zack, DO Clark, DR Lannin, DT Ko, E Hing, EG McFarland, EG Stone, GI Kempen, IM Bennett, JM Robinson, JT DeFrank, JT Hart, K Fiscella, Kevin Fiscella, LC Seeff, ML Margolis, MP Doescher, PA Nutting, PA Nutting, Pat Ford, Paul Winters, PB Bach, PG Szilagyi, Raymond Specht, S Vinker, Samantha K Hendren, Sharon Humiston, Shirley Pope, Starlene Loader, Steven Marcus, T Spadea, TA Jacobson, TD Sequist, U Sarkar   +43 more
core   +4 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source