Results 151 to 160 of about 5,332,530 (372)

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Colorectal Cancer and Nutrition

Nutrients, 2019
Colorectal Cancer is the third most common cancer diagnosed in the US. While the incidence and the mortality rate of colorectal cancer has decreased due to effective cancer screening measures, there has been an increase in number of young patients ...
Kannan Thanikachalam, G. Khan
semanticscholar   +1 more source

Dietary Patterns and Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue [PDF]

, 2018
Importance—Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of host immune response to tumor. Evidence also suggests that diet influences intestinal F. nucleatum. However, the role of F.
Bullman, Susan, Cao, Yin, Chan, Andrew T., Drew, David A., Fuchs, Charles S., Fung, Teresa T., Garrett, Wendy S., Giovannucci, Edward L., Hamada, Tsuyoshi, Huttenhower, Curtis, Kostic, Aleksandar D., Kosumi, Keisuke, Masugi, Yohei, Mehta, Raaj S., Meyerhardt, Jeffrey A., Mima, Kosuke, Nishihara, Reiko, Nowak, Jonathan A., Ogino, Shuji, Qian, Zhi Rong, Song, Mingyang, Willett, Walter C., Wu, Kana, Zhang, Xuehong   +23 more
core   +1 more source

Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer. [PDF]

, 2016
Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial.
Chu, Zhonghua, Hu, Kaishun, Koeffler, H Phillip, Li, Yu, Tian, Huan, Wu, Wenjing, Yan, Haiyan, Yin, Dong   +7 more
core   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Global trends in colorectal cancer mortality: projections to the year 2035

International Journal of Cancer, 2019
Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth most common cause of cancer death. Predictions of the future burden of the disease inform health planners and raise awareness of the need for cancer control action.
M. Araghi, I. Soerjomataram, M. Jenkins, J. Brierley, E. Morris, F. Bray, M. Arnold   +6 more
semanticscholar   +1 more source

Prognostic Impact of Skip Metastasis to the Lateral Lymph Nodes in Lower Rectal Cancer

Journal of the Anus, Rectum and Colon
Objectives: Some patients with lower rectal cancer develop “skip metastasis,” in which lymph node metastasis occurs in the lateral but not the mesenteric lymph nodes. However, the prognostic impact of skip metastasis is unclear.
Sono Ito, Yasuyuki Takamizawa, Konosuke Moritani, Shunsuke Tsukamoto, Yukihide Kanemitsu   +4 more
doaj   +1 more source

Improving Awareness of Colon Cancer Screening in the Homeless Population of Burlington, Vermont [PDF]

, 2018
Homeless populations are significantly less likely to access preventative cancer screening, yet this is a major cause of morbidity and mortality in this population.
Nadeau, Alexis
core   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Strategies for Colorectal Cancer Screening.

Gastroenterology, 2019
The incidence of colorectal cancer (CRC) is increasing worldwide. CRC has high mortality when detected at advanced stages, yet it is also highly preventable.
U. Ladabaum, J. Dominitz, Charles J. Kahi, R. Schoen   +3 more
semanticscholar   +1 more source