Results 151 to 160 of about 5,582,484 (376)

Preoperative T staging using CT colonography with multiplanar reconstruction for very low rectal cancer

BMC Cancer, 2017
Background Preoperative T staging of lower rectal cancer is an important criterion for selecting intersphincteric resection (ISR) or abdominoperineal resection (APR) as well as selecting neoadjuvant therapy.
Dai Shida, Gen Iinuma, Akira Komono, Hiroki Ochiai, Shunsuke Tsukamoto, Mototaka Miyake, Yukihide Kanemitsu   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis

Cell Communication and Signaling, 2018
Background Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer.
Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai, Xinxiang Li   +7 more
doaj   +1 more source

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

JAMA Oncology, 2019
This cohort study investigates the use of longitudinal data from ultradeep sequencing of cell-free DNA in Danish patients with colorectal cancer.
T. Reinert, T. Henriksen, E. Christensen, Shruti Sharma, R. Salari, H. Sethi, Michael Knudsen, I. Nordentoft, Hsin-Ta Wu, Antony S. Tin, Mads Heilskov Rasmussen, Søren Vang, S. Shchegrova, Amanda Frydendahl Boll Johansen, R. Srinivasan, Z. Assaf, M. Balcioğlu, A. Olson, S. Dashner, D. Hafez, S. Navarro, Shruti Goel, M. Rabinowitz, P. Billings, S. Sigurjonsson, L. Dyrskjøt, R. Swenerton, A. Aleshin, S. Laurberg, A. Husted Madsen, A. Kannerup, K. Stribolt, Søren Palmelund Krag, L. Iversen, K. Gotschalck Sunesen, C. J. Lin, B. Zimmermann, C. Lindbjerg Andersen   +37 more
semanticscholar   +1 more source

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

A systematic review of the association between circulating concentrations of C reactive protein and cancer.

, 2007
The objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified.
Ebrahim, Shah, Heikkilä, Katriina, Lawlor, Debbie A   +2 more
core   +1 more source

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer.

New England Journal of Medicine, 2019
BACKGROUND Patients with metastatic colorectal cancer with the BRAF V600E mutation have a poor prognosis, with a median overall survival of 4 to 6 months after failure of initial therapy.
S. Kopetz, A. Grothey, R. Yaeger, E. Van Cutsem, J. Desai, T. Yoshino, H. Wasan, F. Ciardiello, F. Loupakis, Y. Hong, N. Steeghs, T. Guren, H. Arkenau, P. García-Alfonso, P. Pfeiffer, S. Orlov, S. Lonardi, E. Élez, Tae-Woon Kim, J. Schellens, C. Guo, Asha R Krishnan, Jeroen Dekervel, V. Morris, A. Calvo Ferrandiz, L. Tarpgaard, M. Braun, A. Gollerkeri, C. Keir, K. Maharry, M. Pickard, J. Christy-Bittel, L. Anderson, V. Sandor, J. Tabernero   +34 more
semanticscholar   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

The contribution of serum enzymes and carcinoembryonic antigen to the early diagnosis of metastatic colorectal cancer [PDF]

, 1975
E.H. Cooper, Robert D. Turner, Linda Steele, Alan Nevill, Alan Mackay   +4 more
openalex   +1 more source

The tumor–microbe connection

Molecular Oncology, EarlyView.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source