Results 151 to 160 of about 5,474,833 (393)

Colorectal Polyp Segmentation by U-Net with Dilation Convolution [PDF]

arXiv, 2019
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a leading cause of cancer deaths in the United States. Colorectal polyps that grow on the intima of the colon or rectum is an important precursor for CRC. Currently, the most common way for colorectal polyp detection and precancerous pathology is the colonoscopy.
arxiv  

Dietary Patterns and Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue [PDF]

, 2018
Importance—Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of host immune response to tumor. Evidence also suggests that diet influences intestinal F. nucleatum. However, the role of F.
Bullman, Susan, Cao, Yin, Chan, Andrew T., Drew, David A., Fuchs, Charles S., Fung, Teresa T., Garrett, Wendy S., Giovannucci, Edward L., Hamada, Tsuyoshi, Huttenhower, Curtis, Kostic, Aleksandar D., Kosumi, Keisuke, Masugi, Yohei, Mehta, Raaj S., Meyerhardt, Jeffrey A., Mima, Kosuke, Nishihara, Reiko, Nowak, Jonathan A., Ogino, Shuji, Qian, Zhi Rong, Song, Mingyang, Willett, Walter C., Wu, Kana, Zhang, Xuehong   +23 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.

, 1993
Background The current practice of removing adenomatous polyps of the colon and rectum is based on the belief that this will prevent colorectal cancer. To address the hypothesis that colonoscopic polypectomy reduces the incidence of colorectal cancer, we
S. Winawer, A. Zauber, M. N. Ho, M. O'brien, L. Gottlieb, S. Sternberg, J. Waye, M. Schapiro, J. Bond, J. Panish   +9 more
semanticscholar   +1 more source

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Nature Network Boston, 2019
Association studies have linked microbiome alterations with many human diseases. However, they have not always reported consistent results, thereby necessitating cross-study comparisons.
J. Wirbel, P. Pyl, Ece Kartal, Konrad Zych, A. Kashani, A. Milanese, J. S. Fleck, A. Voigt, A. Pallejà, R. Ponnudurai, S. Sunagawa, Luis Pedro Coelho, P. Schrotz-King, E. Vogtmann, N. Habermann, E. Niméus, A. M. Thomas, P. Manghi, S. Gandini, D. Serrano, Sayaka Mizutani, H. Shiroma, Satoshi Shiba, T. Shibata, S. Yachida, Takuji Yamada, L. Waldron, A. Naccarati, N. Segata, R. Sinha, C. Ulrich, H. Brenner, Manimozhiyan Arumugam, P. Bork, G. Zeller   +34 more
semanticscholar   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

The Effect of Race/Ethnicity on the Age of Colon Cancer Diagnosis

, 2013
BACKGROUND: Colorectal cancer is the third most commonly diagnosed cancer in the United States. Notably, racial/ethnic disparities exist in both incidence and mortality.
Bergamaschi, Roberto, Katz, Matthew, Li, Ellen, Parrish, Maryann E., Shroyer, Kenneth, Williams, Jennie L., Zhang, Yuanhao, Zhu, Wei   +7 more
core  

Improving Awareness of Colon Cancer Screening in the Homeless Population of Burlington, Vermont [PDF]

, 2018
Homeless populations are significantly less likely to access preventative cancer screening, yet this is a major cause of morbidity and mortality in this population.
Nadeau, Alexis
core   +1 more source

Preferences for cancer investigation:a vignette-based study of primary-care attendees [PDF]

, 2014
SummaryBackgroundThe UK lags behind many European countries in terms of cancer survival. Initiatives to address this disparity have focused on barriers to presentation, symptom recognition, and referral for specialist investigation. Selection of patients
Banks, Jonathan, Bigwood, Lin, Hamilton, Willie, Hollinghurst, Sandra, Peters, Tim J, Walter, Fiona M   +5 more
core   +1 more source