FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Why do some participants in colorectal cancer screening choose not to undergo colonoscopy following a positive test result? A qualitative study [PDF]
, 2018 Anne Katrine Lykke Bie, John Brodersen
openalex +1 more source
Global patterns and trends in colorectal cancer incidence and mortality
Gut, 2016 M. Arnold +5 more
semanticscholar +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population [PDF]
, 2014 Qi Wang +4 more
openalex +1 more source
Dietary Patterns and Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue [PDF]
, 2018 Importance—Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of host immune response to tumor. Evidence also suggests that diet influences intestinal F. nucleatum. However, the role of F.
Bullman, Susan +23 more
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
2-Hydroxymelatonin, a Predominant Hydroxylated Melatonin Metabolite in Plants, Shows Antitumor Activity against Human Colorectal Cancer Cells [PDF]
, 2017 Yi Yang +6 more
openalex +1 more source
Prevalensi Kanker Kolorektal Di Rumah Sakit Immanuel Bandung Periode Januari 2005 ─ Desember 2007 [PDF]
, 2009 Colorectal cancer is the most common gastrointestinal Malignancy. In Indonesia, colorectal cancer is on the sixth position of ten Malignant cancers mostly suffered. The data from the Health Department show the prevalence 1.8 per 100,000 population.
Ivone, J. (July) +2 more
core
Aging and Cancer, EarlyView.Colorectal cancer (CRC) mortality is highest in aged males. Pre‐clinical data comparing CRC i.p. metastasis in cohorts of young and aged, male and female mice support these finding. Bottom‐up proteomics of peritoneal mesothelial cells identified PTP4A1 as highly expressed in aged males and a role for PTP4A1 in heterotypic cell:cell adhesion was ...
Zhikun Wang +17 more
wiley +1 more source