Results 291 to 300 of about 5,582,484 (376)
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu+8 more
wiley +1 more source
Interval colorectal cancer: Lesson from looking back. [PDF]
Aldinio G+6 more
europepmc +1 more source
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang+6 more
wiley +1 more source
Colorectal cancer epidemiology (1990-2050): lessons from the Australasian experience. [PDF]
Yao B+7 more
europepmc +1 more source
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen+18 more
wiley +1 more source
Prognostic Significance of the Comprehensive Biomarker Analysis in Colorectal Cancer. [PDF]
Potievskaya V+10 more
europepmc +1 more source
Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen+22 more
wiley +1 more source