Results 71 to 80 of about 5,673,125 (350)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis

Radiation Oncology, 2017
Background This study aimed to evaluate the efficacy of a high dose of oral tegafur-uracil (400 mg/m2) plus leucovorin with preoperative chemoradiation of locally advanced rectal cancer and to explore the impact of polymorphisms of cytochrome P 2A6 ...
Sun Young Kim, Ji Yeon Baek, Jae Hwan Oh, Sung Chan Park, Dae Kyung Sohn, Min Ju Kim, Hee Jin Chang, Sun-Young Kong, Dae Yong Kim   +8 more
doaj   +1 more source

The impact of old age on cancer-specific and non-cancer-related survival following elective potentially curative surgery for Dukes A/B colorectal cancer [PDF]

, 2008
Previous studies have suggested that survival following surgery for colorectal cancer is poorer in the elderly. However, the findings were inconsistent and none of the studies adjusted for case mix.
Hole, D.J., McArdle, C.S., McMillan, D.C.   +2 more
core   +2 more sources

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nature Communications, 2020
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded.
N. Papadimitriou, N. Dimou, K. Tsilidis, B. Banbury, Richard M. Martin, S. Lewis, N. Kazmi, T. Robinson, D. Albanes, K. Aleksandrova, S. Berndt, D. Timothy Bishop, H. Brenner, D. Buchanan, B. Bueno-de-Mesquita, P. Campbell, S. Castellví-Bel, A. Chan, J. Chang-Claude, M. Ellingjord-Dale, J. Figueiredo, S. Gallinger, G. Giles, E. Giovannucci, S. Gruber, A. Gsur, J. Hampe, H. Hampel, Sophia Harlid, T. Harrison, M. Hoffmeister, J. Hopper, L. Hsu, José María Huerta, J. Huyghe, M. Jenkins, T. Keku, T. Kühn, C. la Vecchia, L. Le Marchand, Christopher I. Li, Li Li, A. Lindblom, N. Lindor, B. Lynch, S. Markowitz, G. Masala, A. May, R. Milne, E. Monninkhof, Lorena Moreno, V. Moreno, P. Newcomb, K. Offit, Vittorio Perduca, P. Pharoah, E. Platz, J. Potter, G. Rennert, E. Riboli, María-José Sánchez, S. Schmit, R. Schoen, G. Severi, S. Sieri, M. Slattery, M. Song, C. Tangen, S. Thibodeau, R. Travis, A. Trichopoulou, C. Ulrich, F. V. van Duijnhoven, B. van Guelpen, P. Vodicka, E. White, A. Wolk, M. Woods, A. Wu, U. Peters, M. Gunter, N. Murphy   +81 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Prophylactic stoma in robotic radical surgery for low-to-intermediate rectal cancer

Clinical Surgical Oncology
Background: Anastomotic leakage are common and serious complications after surgery for low and intermediate rectal cancers; a prophylactic stoma is thought to reduce the incidence of anastomotic leakage and alleviate its serious complications.
Zhekun Huang, Songbin Lin, Peiwen Zhou, Yang Lv, Guodong He, Ye Wei, Jianmin Xu, Wentao Tang   +7 more
doaj   +1 more source

Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort

BMC Cancer, 2019
Background Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification.
Ann C. Eriksen, Flemming B. Sørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt, Torben F. Hansen   +6 more
doaj   +1 more source

UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer

Cell Death and Disease, 2021
UPF1 is proved to dysregulate in multiple tumors and influence carcinogenesis. However, the role of UPF1 in oxaliplatin resistance in colorectal cancer (CRC) remains unknown.
Congcong Zhu, Long Zhang, Senlin Zhao, Weixing Dai, Yun Xu, Yuqin Zhang, Hongtu Zheng, Weiqi Sheng, Ye Xu   +8 more
doaj   +1 more source

Creation of a Novel Nomogram Based on the Direct Bilirubin-To-Indirect Bilirubin Ratio and Lactate Dehydrogenase Levels in Resectable Colorectal Cancer

Frontiers in Molecular Biosciences, 2021
Background: Recently, many studies have suggested that bilirubin is associated with the prognosis of colorectal cancer (CRC). Conversely, there is substantial evidence that lactate dehydrogenase (LDH) levels are associated with the prognosis of cancer ...
Yifei Ma, Yifei Ma, Yifei Ma, Lulu Shi, Lulu Shi, Ping Lu, Ping Lu, Ping Lu, Shuang Yao, Shuang Yao, Hongli Xu, Hongli Xu, Hongli Xu, Junjie Hu, Junjie Hu, Junjie Hu, Xin Liang, Xin Liang, Xin Liang, Xinjun Liang, Xinjun Liang, Xinjun Liang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei   +24 more
doaj   +1 more source

Improving Awareness of Colon Cancer Screening in the Homeless Population of Burlington, Vermont [PDF]

, 2018
Homeless populations are significantly less likely to access preventative cancer screening, yet this is a major cause of morbidity and mortality in this population.
Nadeau, Alexis
core   +1 more source